Allison Elliott-Shannon

By

College: Medicine

Alzheimer’s Disease Trial at UK is First of its Kind Worldwide

Published: Dec 2, 2013

 

LEXINGTON, Ky. (Dec. 2, 2013) – A new clinical trial being conducted at the University of Kentucky Sanders-Brown Center on Aging (SBCoA) and the UK Alzheimer’s Disease Center (ADC) may signal new hope in the future for those who might be afflicted with the devastating disease. Taking laboratory research pioneered at SBCoA and the associated UK ADC into human trials, the federally-funded research project will examine the therapeutic potential of microRNAs to delay or prevent Alzheimer’s disease.

 

Led by physician-scientist Dr. Gregory Jicha, and building off of the work of fellow SBCoA physician-scientist Dr. Peter Nelson, the project, formally titled “Modulation of micro-RNA pathways by gemfibrozil in pre-dementia Alzheimer disease,” will operate with a total budget of $1.5 million over three years. Funding was awarded by the National Institute on Aging as the result of a competitive process.

 

In 2006, the Nobel Prize was awarded for the discovery of microRNA biology. MicroRNAs are now understood by scientists to be implicated in health and disease states for hundreds of conditions. However, despite advances in microRNA technology, to date no group in the world has been able to apply microRNA discoveries in human clinical trials to affect neurodegenerative disease states.

 

“We are currently funded by the NIA/NIH and approved to take Dr. Pete Nelson's microRNA discoveries into the first-ever human clinical trial of microRNA modulation to influence a disease state. This trial is just starting, but it is not a hope or future expectation, it is real today,” said Jicha. “The microRNA project at the University of Kentucky is the first trial in the history of mankind to test the therapeutic potential of microRNAs in modulating neurodegenerative disease states. If our discovery is successful it will open the door for untold therapeutic developments for the diseases that plague us all as we age.”

 

As background, Jicha explained that, “Many have heard the speculation that more than 90 percent of our DNA is ‘junk’. The truth is that if we had ‘junk’, it would have been weeded out evolutionarily.”

 

In reality, at least some of this DNA codes for small fragments of RNA that regulate gene expression in health and disease states. These small RNA fragments are called microRNA. In previous work, Nelson of SBCoA has been able to show that one such microRNA is reduced in the brain very early as Alzheimer’s disease pathology begins.

 

“Nelson’s evidence suggests that if we can increase the levels of this microRNA, we may be able to prevent Alzheimer’s disease, or even stop it when it is in its earliest stages,” said Jicha.

Fortunately, a FDA-approved drug that can increase miRNA-107 levels already exists, and is currently approved for treating high cholesterol. In cell culture experiments this drug, called gemfibrozil, can prevent Alzheimer’s disease-associated changes.

 

Gemfibrozil is one of a class of drugs called fibrates, currently used worldwide to treat high cholesterol. Previous studies of people taking fibrates have consistently demonstrated an approximately 50 percent reduction in risk for Alzheimer’s disease.

 

“In U.S. terms,” said Jicha, “that could potentially cut the burden of Alzheimer’s from 5.4 million cases to 2.7 million nationwide.”

 

“This innovative clinical trial is a great example of the ‘bench to bedside’ focus of the UK Sanders-Brown Center on Aging – taking a research discovery made in the laboratory and translating that knowledge into a human clinical study.  This pioneering clinical study testing the therapeutic potential of microRNAs to delay or prevent Alzheimer’s disease clearly shows how Pete Nelson and Greg Jicha, and the Sanders-Brown Center on Aging, are leading the world in testing promising new approaches to Alzheimer’s therapy,” said Linda Van Eldik, director of the Sanders-Brown Center on Aging.

 

Watch Dr. Jicha discuss the importance of clinical trials to Alzheimer's research below:

 

 

 

###

 

At this time, UK researchers are looking for participants with normal memory and thinking or very mild memory problems, who would like to help us test the medicine for the prevention of Alzheimer’s disease. Potential participants cannot already be on a cholesterol lowering medicine, so they are looking for participants with normal or only mildly elevated cholesterol levels that are not on treatment. For more information on the trial call the Sanders-Brown Center on Aging at 859-323-5550.

 

research_volunteers.jpgjicha.jpg
March
1
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
2
Wildcat Wellness: Expressions (Creative Stress Relief)
Resume & Cover Letters that Work
Mon
3
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Grad Salute
2nd Annual UK Work-Life Summer Camps Fair
UK Elder Care Lunch & Learn - Keeping Your Brain Healthy
Successful Networking & Job Search
Guest Lecture
Documentary Screening: "Forgotten Wars, Forgotten Victims"
Bangladeshi Garment Worker Speak Out
A Reading by Nic Brown
CatWatch Party #3
Tue
4
LNFS Presents: The Mighty Ducks
Wildcat Wellness: Meditation
Internship Info Session
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Art Therapy Table
OUTspoken with J Mase III
Appalachian Forum with Crystal Wilkinson entitled: Birds of Opulence: Black Women, Madness, and Resilience in Appalachia
Wed
5
LNFS Presents: Typeface
LNFS Presents: Space Jam
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Food for Hope
Thu
6
LNFS Presents: A Girl Walks Home Alone at Night
LNFS Presents: Pokémon: The First Movie
Cultural Coffee Hour
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Japan Today
Holi: The Indian Festival of Colors
Fri
7
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Karnival Around The World
Graduate & Professional School Prep:KAPLAN Free Practice Test for MCAT and LSAT
PharmD Open House
Sat
8
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
9
Midterm of 2015 Spring Semester
Wildcat Wellness: Expressions (Creative Stress Relief)
GUEST LECTURE
Appalachian Forum with Rebecca Klenk, Topic: Global Uttarakhand: Development, Neoliberalism and Social Justice in Himalayan India
Ballroom Thieves
Mon
10
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: Staying Positive During A Job Search
Massage on the Go #2
Tue
11
LNFS Presents: Only Lovers Left Alive
Wildcat Wellness: Meditation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Jin Shin Jyutsu Self-Help Class
Leadership Assessment
#TrendingTopics: Immunization
True Songs
Wed
12
LNFS Presents: Into the Woods
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
LNFS Presents: Waiting for 'Superman'
Thu
13
LNFS Presents: Vertigo
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
LNFS Presents: Trainspotting
Fri
14
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
15
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
16
Spring 2015 Spring Vacation
Mon
17
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Tue
18
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wed
19
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Thu
20
Spring 2015 Spring Vacation
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Plating Design Demonstration with Dan Wu
Fri
21
Spring 2015 Spring Vacation
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
22
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
23
Wildcat Wellness: Expressions (Creative Stress Relief)
"Thrive: The Kentucky Wine Tradition" Documentary Screening
Mon
24
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: A Snapshot of the Central Kentucky Labor Market
Career & Major Exploration Session @ 1 p.m.
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Kentucky Teacher's Network Career Fair
Tue
25
LNFS Presents: Rear Window
Wildcat Wellness: Meditation
Internship Info Session
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Healthy Smoothie Demonstration
Virtual Dementia Tour
Career & Major Exploration Session @ 1 p.m.
Healthy Smoothie Demonstration
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Women of the World: Rosario Dawson
Wed
26
LNFS Presents: The Imitation Game
LNFS Presents: Blade Runner
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Student & Employer Mixer
Young Artists Exhibit Reception
Thu
27
LNFS Presents: Psycho
LNFS Presents: The Life Aquatic with Steve Zissou
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Fri
28
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
29
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Lion King Trip
Sun
30
Wildcat Wellness: Expressions (Creative Stress Relief)
Mon
31
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Tue
 
 
 
 

Repeats every week until Thu Apr 30 2015 except Tue Mar 17 2015.
Tue, 03/03/2015

Repeats every day on January, February, March, April every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Apr 12 2015 except Mon Jan 12 2015, Mon Jan 26 2015, Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Tue, 03/03/2015

Repeats every day until Sun Apr 12 2015 except Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Tue, 03/03/2015

Repeats every day until Sun Apr 12 2015 except Mon Jan 26 2015, Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Tue, 03/03/2015

Repeats every day until Sun Apr 12 2015 except Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Tue, 03/03/2015

Reset Page