Allison Elliott-Shannon

By

College: Medicine

Research Sheds New Light on Traumatic Brain Injuries

Published: Apr 16, 2013

LEXINGTON, Ky. (April 16, 2013) — Even a mild injury to the brain can have long lasting consequences, including increased risk of cognitive impairment later in life. While it is not yet known how brain injury increases risk for dementia, there are indications that chronic, long-lasting, inflammation in the brain may be important. A new paper by researchers at the University of Kentucky Sanders-Brown Center on Aging (SBCoA), appearing in the Journal of Neuroscience, offers the latest information concerning a “switch” that turns “on” and “off” inflammation in the brain after trauma.

 

A team of researchers led by Linda Van Eldik, director of SBCoA, used a mouse model to study the role of p38a MAPK in trauma-induced injury responses in the microglia resident immune cell of the brain.

 

“The p38α MAPK protein is an important switch that drives abnormal inflammatory responses in peripheral tissue inflammatory disorders, including chronic debilitating diseases like rheumatoid arthritis,” said Van Eldik.

 

“However, less is known about the potential importance of p38α MAPK in controlling inflammatory responses in the brain. Our work supports p38α MAPK as a promising clinical target for the treatment of CNS disorders associated with uncontrolled brain inflammation, including trauma, and potentially others like Alzheimer’s disease. We are excited by our findings, and are actively working to develop drugs targeting p38a MAPK designed specifically for diseases of the brain.”

 

Lead author of the paper Adam D. Bachstetter said, “I was surprised when I looked under the microscope at the brain tissue of mice that had a diffuse brain injury. Microglia normally look like a small spider, but after suffering a brain injury the microglia become like angry spiders from a horror movie. In brain-injured mice that lack p38a MAPK there were no angry-looking microglia, only the normal small spider-like cells. When I started the study I never expected the results to be so clear and striking. I believe that the p38a MAPK is a promising clinical target for the treatment of CNS disorders with dysregulated inflammatory responses, but we are still a long way from development of CNS-active p38 inhibitor drugs.”

 

The paper, "The p38a MAPK regulates microglial responsiveness to diffuse traumatic brain injury," is from a team of researchers including Linda Van Eldik, as well as Adam Bachstetter, Machi Kaneko and Danielle Goulding of SBCoA; and Rachel K. Rowe and Jonathan Lifshitz, director of the Translational Neurotrauma Research Program, Barrow Neurological Institute at Phoenix Children's Hospital in Arizona.

 

 

 

MEDIA CONTACT: Allison Elliott, Allison.Elliott@uky.edu

istock_000005809739xsmall-1_0.jpg
September
 
 
1
Last Day to Add a Class
Last Day to Receive 80% Refund
Suicide Prevention: Raising Awareness & Sharing Our Stories
Welcome Coffee
Game Show
Tue
2
Wildcat Wellness Meditation
Wed
3
Essay Contest for Constitution Day 2015
The Late Night Film Series Presents - Rosemary's Baby
The Late Night Film Series Presents - Pitch Perfect 2
Adjusting to College
Adjusting to College
Kickoff Football Season Grill Out
Thu
4
Essay Contest for Constitution Day 2015
The Late Night Film Series Presents - Akira
The Late Night Film Series Presents - Whiplash
To Live in the Borderlands: A Household Perspective on Frontier Politics from the Middle Jequetepeque Valley, Peru
Fri
5
Essay Contest for Constitution Day 2015
Go Swing Dancing!
Sat
6
Essay Contest for Constitution Day 2015
Sun
7
Essay Contest for Constitution Day 2015
Labor Day
Mon
8
Essay Contest for Constitution Day 2015
Wildcat Wellness Relaxation
The Late Night Film Series Presents - Ivory Tower
Tue
9
Essay Contest for Constitution Day 2015
Wildcat Wellness Meditation
Wed
10
Essay Contest for Constitution Day 2015
The Late Night Film Series Presents - Selena
The Late Night Film Series Presents - Jurassic World
Adjusting to College
Terrace Time Out
Thu
11
Essay Contest for Constitution Day 2015
The Late Night Film Series Presents - The Great Beauty
The Late Night Film Series Presents - Predator
Friday Swing Dance Lessons - Free!
Friday Swing Dance Lessons - Free!
Accounting Internship & Career Fair
Fri
12
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wayne Koestenbaum: Unfamiliar Grammar
Sculptors On Paper
Swing Dance Lessons - Free
Sat
13
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Sun
14
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Kentucky Law Schools Forum
Outdoor Installation
Wildcat Wellness Expressions - Superhero
Mon
15
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Outdoor Installation
Wildcat Wellness Relaxation
Women's Forum Board Meeting
Southern Sirens Concert
Tue
16
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Outdoor Installation
Wildcat Wellness Meditation
Last Day to Drop a Course Without Appearing on Transcript
Wed
17
Essay Contest for Constitution Day 2015
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Outdoor Installation
Adjusting to College
Interactive Issues Graffiti Wall for Constitution Day: "What Civic Issues are Most Important to You?"
Voter Registration and Information on Student Civic Engagement
Citizen Kentucky Project for Constitution Day 2015
Advocacy through Digital Citizenship
"Picking Cotton" in Context: A Discussion on Issues from the Common Reading Experience book
Thu
18
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Essay Contest for Constitution Day 2015
Outdoor Installation
The Late Night Film Series Presents - Dark Girls
The Late Night Film Series Presents - The Pokémon Movie
LexPhil Pre-Concert Buffet
Curator Tour with Stuart Horodner
Fri
19
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Swing Dance Lessons - Free
Sat
20
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
LexHop
Sun
21
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wildcat Wellness Expressions - Finger Painting
Mon
22
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wildcat Wellness Relaxation
Tue
23
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wildcat Wellness Meditation
Last Day to Receive 50% Refund
Thank-A-Donor Day
2 Day Business Internship & Career Fair
Pinterest Party I
Wed
24
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
2 Day Business Internship & Career Fair
Wildcat Wellness - Yoga for Relaxation
Wildcat Wellness - Yoga for Relaxation
Wildcat Wellness - Yoga for Relaxation
Wildcat Wellness - Yoga for Relaxation
Wildcat Wellness - Yoga for Relaxation
The Late Night Film Series Presents - Wild Tales
The Late Night Film Series Presents - Mad Max: Fury Road
Adjusting to College
Thu
25
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wayne Koestenbaum: Unfamiliar Grammar
The Late Night Film Series Presents - All.I.Can
The Late Night Film Series Presents - Nightcrawler
Fri
26
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Paint the Town Blue/Banner Competition
Wayne Koestenbaum: Unfamiliar Grammar
Swing Dance Lessons - Free
Swing Dance Lessons - Free
Arts Writing Workshop
Sat
27
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Paint the Town Blue/Banner Competition
Wayne Koestenbaum: Unfamiliar Grammar
Sun
28
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Paint the Town Blue/Banner Competition
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wildcat Wellness Expressions - Mandala
Mon
29
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wildcat Wellness Relaxation
Wildcat Wellness Relaxation
Wayne Koestenbaum: Unfamiliar Grammar
Kitty Karnival
Tue
30
Bottoms Up: A Sculpture Survey
Nina Katchadourian: Collection Interventions
Wildcat Wellness Meditation
Wildcat Wellness Meditation
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wayne Koestenbaum: Unfamiliar Grammar
Wed
 
 
 

Thu, 09/03/2015

Repeats every week until Fri Sep 11 2015 .
Fri, 09/04/2015

Reset Page