Allison Elliott-Shannon

By

College: Medicine

Research Sheds New Light on Traumatic Brain Injuries

Published: Apr 16, 2013

LEXINGTON, Ky. (April 16, 2013) — Even a mild injury to the brain can have long lasting consequences, including increased risk of cognitive impairment later in life. While it is not yet known how brain injury increases risk for dementia, there are indications that chronic, long-lasting, inflammation in the brain may be important. A new paper by researchers at the University of Kentucky Sanders-Brown Center on Aging (SBCoA), appearing in the Journal of Neuroscience, offers the latest information concerning a “switch” that turns “on” and “off” inflammation in the brain after trauma.

 

A team of researchers led by Linda Van Eldik, director of SBCoA, used a mouse model to study the role of p38a MAPK in trauma-induced injury responses in the microglia resident immune cell of the brain.

 

“The p38α MAPK protein is an important switch that drives abnormal inflammatory responses in peripheral tissue inflammatory disorders, including chronic debilitating diseases like rheumatoid arthritis,” said Van Eldik.

 

“However, less is known about the potential importance of p38α MAPK in controlling inflammatory responses in the brain. Our work supports p38α MAPK as a promising clinical target for the treatment of CNS disorders associated with uncontrolled brain inflammation, including trauma, and potentially others like Alzheimer’s disease. We are excited by our findings, and are actively working to develop drugs targeting p38a MAPK designed specifically for diseases of the brain.”

 

Lead author of the paper Adam D. Bachstetter said, “I was surprised when I looked under the microscope at the brain tissue of mice that had a diffuse brain injury. Microglia normally look like a small spider, but after suffering a brain injury the microglia become like angry spiders from a horror movie. In brain-injured mice that lack p38a MAPK there were no angry-looking microglia, only the normal small spider-like cells. When I started the study I never expected the results to be so clear and striking. I believe that the p38a MAPK is a promising clinical target for the treatment of CNS disorders with dysregulated inflammatory responses, but we are still a long way from development of CNS-active p38 inhibitor drugs.”

 

The paper, "The p38a MAPK regulates microglial responsiveness to diffuse traumatic brain injury," is from a team of researchers including Linda Van Eldik, as well as Adam Bachstetter, Machi Kaneko and Danielle Goulding of SBCoA; and Rachel K. Rowe and Jonathan Lifshitz, director of the Translational Neurotrauma Research Program, Barrow Neurological Institute at Phoenix Children's Hospital in Arizona.

 

 

 

MEDIA CONTACT: Allison Elliott, Allison.Elliott@uky.edu

istock_000005809739xsmall-1_0.jpg
August
 
 
 
 
 
1
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
2
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
3
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Artful Sunday: Wrapped Art
Sun
4
Employee Educational Assistance Award
Mon
5
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
6
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
7
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
8
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
9
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
10
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
11
Employee Educational Assistance Award
Mon
12
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
UK Working Moms Connection
Tue
13
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Wed
14
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
15
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
16
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
17
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
18
Employee Educational Assistance Award
Mon
19
Employee Educational Assistance Award
Tue
20
Employee Educational Assistance Award
Chronic Disease Self-Management Program
Wed
21
Employee Educational Assistance Award
Thu
22
Employee Educational Assistance Award
Midnight Dodgeball Tournament
CARES First Year Focus Parent Meetings
CARES First Year Focus Parent Meetings
Parent and Families Reception
Residence Hall Floor Meeting
Off-campus Freshmen Check-in
K Team Meeting: K Week Kick-off
Death By Chocolate
Fri
23
Employee Educational Assistance Award
A Parent's Guide to Life after August 23
Campus Safety Information Session
Donut Avoid The Study
Common Cents: Money Management for College Students Session 1
See Blue...See Community
Succeeding in A Large Lecture Classroom
Horses, Bluegrass, Basketball, and More: Welcome to Kentucky
Success at Any Age: College Tips for Adult Learners
Write Right: Tips for Writing Well in College
Common Cents: Money Management for College Students Session 2
How to Graduate in Four Years
Parental Involvement in Fraternity and Sorority Life
Parents Watch for Warning Signs: Suicide Prevention for College Students
Preparing to be a Pre-Professional
Presentation U!: Where YOU are the Ultimate Presentation
Religious Life at UK
Successful Off-Campus Living
The Transfer Student Cruise: Navigating your way through UK
UK Parking & Transportation 101
You Heard It Here First: Tips From A Faculty Member
New Student Induction Ceremony
Minority Student Welcome
Transfer Student Cookout
K Team Meeting: K Week Overview
Men's Soccer vs. Georgia State
Big Blue U
Campus Ruckus
Campus Ruckus
Sat
24
Employee Educational Assistance Award
LNFS Presents: Jackass 3
LNFS Presents: Godzilla
Pedalpalooza
K Team Meeting: Lunch and Campus Tour
Center for Community Outreach: Do Good, Start Here.
UK Lex-Mart
Alternative Service Breaks: See the World, Change the World
From the Real World to the Amazing Race, Don't Wipeout: Your Advisor, Advising, and You
Blackboard Basics
Student Government Association Information Session
EMPOWER: Women’s Leadership Retreat Interest Session
Student Center Spectacular
Student Center Spectacular
Sun
25
Employee Educational Assistance Award
UK FUSION
UK Parking & Transportation 101
University of Kentucky Association for Transfer Students Interest Session
Candy, Condoms, Coffee
Cleaner, Healthier, Cheaper, Faster: Why Bicycling is the Best Way to Get Around Campus (and how to do it safely)
Working on Campus
K Team Meeting: Dinner with your K Team
Meijer Mania
Mon
26
Employee Educational Assistance Award
Last Day to Drop a Course with 100% Refund
Chem at UK Cafe-N-OJ with the Student American Chemical Society
Coffee (or Coke), Cookies, & Communication!: Come see blue. at Presentation U!
Don't Blow Yourself Up: Surviving Chemistry
Fraternity Recruitment Info Session
OMG! Did I Just E-Mail That to My Professor???
Surviving Your First Year and Beyond: Strategies To Do Well in Your Classes
Sustainable UK: Exploring Environmental Programs in the College of Agriculture, Food, and Environment (CAFE)
A User Guide for Your Mathematics Class
Discover the UK Art Museum
K Team Meeting: Common Reading Experience Discussion
Common Reading Introduction for International Students
Transfer Student Meet and Greet
We Are UK
Rec 'N Roll 2014
Big Blue Bingo Night
Mic Check
Tue
27
Employee Educational Assistance Award
Fraternity Recruitment Info Session
LNFS Presents: Jurassic Park
First Day of Classes
Campus Outreach
Opening Act: The Amazing Spider-Man 2
Wed
28
Employee Educational Assistance Award
Internship Info Session
LNFS Presents: Her
LNFS Presents: Captain America: The Winter Soldier
Student Involvement Fair
OrgSync Info session
LGBTQ* Welcome Back
Dive Into Diversity!
Residence Hall Floor Meetings
Thu
29
Employee Educational Assistance Award
Sea of Blue
One Last Beach Bash: RSA Block Party
LNFS Presents: Team America: World Police
Pills and Pizza
K Week Event: Pills and Pizza
Kentucky Volleyball vs. Wichita State
Kentucky Women's Soccer vs. Francis Marion
Fri
30
Employee Educational Assistance Award
LNFS Presents: Neighbors
The Tailgate "Kick-Off"
Kentucky Volleyball vs. Butler
Kentucky Football vs. UT-Martin
Kentucky Volleyball vs. Virginia Tech
Sat
31
Employee Educational Assistance Award
Kentucky Women's Soccer vs. Ohio
Men's Soccer vs. Belmont
Sun
 
 
 
 
 
 
Aug 22
Midnight Dodgeball Tournament 08/22/2014
Reset Page