Laura Dawahare

Sanders-Brown Research Presentation Garners Hirano Prize

Published: Jul 22, 2014
LEXINGTON, Ky. (July 22, 2014) — Dr. Peter T. Nelson of the Sanders-Brown Center on Aging (SBCoA) at the University of Kentucky, and David Fardo of UK's Department of Biostatistics, have been awarded the 2014 Asao Hirano Prize from the American Association of Neuropathologists (AANP) for the best paper presented on neurodegenerative diseases at its annual meeting in Portland, Oregon, last month.

 

The team's research, titled "Hippocampal Sclerosis of Aging (HS-A): Connecting Genomics and Other Risk Factor Data," compared 363 persons with autopsy-proven HS-A to a control group of 2,303 other individuals in an attempt to identify genetic predisposition to HS-A in what's called a genome-wide association study (GWAS).

 

GWA studies are a relatively new way to explore the linkage between any disease and the genetic factors that may contribute to them. Using the DNA of similar people with the target disease and without, millions of genetic variants are read and analyzed in an attempt to mark a region of the human genome that influences the risk of the target disease. In contrast to methods that specifically test one or a few genetic regions, the GWA studies investigate the entire genome.

 

Nelson and Fardo found that small changes in the ABCC9 gene — also known as Sulfonylurea Receptor 2 — strongly paralleled the incidence of HS-A.  Further statistical analysis indicated a link between the use of sulfonylurea, a medication commonly used to treat diabetes, and an increased risk for HS-A.  

 

"GWA studies require a lot of statistical firepower to tease out subtle relationships between gene mutations and disease, and Dave's expertise was essential to the project," Nelson said.

"While certainly there's a lot more work to be done to confirm the drug-disease interaction, this study nonetheless describes a novel dementia risk factor."

 

Hippocampal Sclerosis of Aging (HS-A) is a condition that affects up to 15 percent of individuals over age 85.  Its symptoms are so similar to those of Alzheimer's disease that patients are often misdiagnosed with the latter.  Currently, the only way to confirm a diagnosis of HS-A is by autopsy.

 

The Hirano Prize is a fitting acknowledgement of Sanders-Brown's research expertise in all areas of neurodegenerative disease, according to Dr. Linda Van Eldik, SBCoA director.

 

"When people think of Sanders-Brown, they think of Alzheimer's disease," Van Eldik said. "But we have people like Pete whose research is making a tangible impact on many other neurodegenerative diseases, including Parkinson's, HS-A, stroke and other dementias. We're delighted that Pete and Dave have been recognized for what is some statistically powerful work."

 

The Hirano prize is named for famed neuropathologist Asao Hirano, who first described the tell-tale structures in nerve cells that indicate the presence of certain neurodegenerative diseases such as Alzheimer's disease. 

 

Nelson wasn't the only one from UK participating at the meeting. Dr. Craig Horbinski delivered a talk and chaired a session on brain cancer and also gave input at the association's journal editorial board. Dr. Vanessa Smith, a pathology resident and future neuropathology fellow, gave a presentation about a patient at the University of Kentucky with a rare neurodegenerative disease. 

 

"These teams and individuals exemplify the world-beating standard that can be achieved in our clinical and research endeavors at SBCoA," Dr. Nelson said.  

 

The American Association of Neuropathologists (AANP) is a professional and educational organization representing more than 800 American neuropathologists. The AANP's purpose is to advance the science, teaching and training of the diseases of the nervous system and the practice of neuropathology.

 

The University of Kentucky’s Sanders-Brown Center on Aging was established in 1979 and is one of the original 10 National Institutes of Health (NIH)-funded Alzheimer’s disease research centers. The SBCoA is internationally acclaimed for its progress in the fight against illnesses facing the aging population. 

nelson2_nov2013.jpgdavidfardo.jpg
February
 
1
Graduate Student Congress Meeting (February)
Mon
2
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Tue
3
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Last Day to Drop a Course Without Appearing on Transcript
Wed
4
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Undergraduate Research Information Session
Thu
5
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Off-Campus Student Services' Wildcat Apartment Hop #1
Panel Discussion: Historic Homes
Fri
6
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
7
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
8
K Crew Recruitment
Sex and Chocolate
Law School Prep Workshop
Mon
9
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Healthy Relationships Workshop
How to Package Communication and Technical Skills on your Resume
2016 Distinguished Industry Lecture Series
Tue
10
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Last Day to Receive 50% Refund
Pinterest Party #1
Get Yourself Tested!
Off-Campus Student Association Information Session
Showcase your Talents: Building a Strong Portfolio
An Evening with Tatyana Ali and Amir Windom: Progression Towards Success
How to Survive a Plague
Wed
11
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Coffee & Canvases
Off-Campus Student Association Information Session
Study Abroad in Berlin!
Horticulture Club Valentine's Day Sale
Thu
12
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Horticulture Club Valentine's Day Sale
Ash and the Market: Ceramic Exchange, Political Economy, and the Late to Terminal Classic Transformation of the Kiuic Polity
Fri
13
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Learn to Play Bridge
Workshop: The Artist Statement
Sat
14
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
15
K Crew Recruitment
See ICT
Patterson School Guest Speaker Series
Mon
16
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
See ICT
UK Women's Forum February Board Meeting
Tue
17
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Food For Thought
Wed
18
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Undergraduate Research Information Session
Soup & Substance: Real Talk, Real Issues, & Real People Series
Thu
19
PharmD Interviews
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Off-Campus Student Services' Wildcat Apartment Hop #2
SAB Underground Formal
Fri
20
PharmD Interviews
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
21
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
22
Undergraduate Research Information Session
University Health Service- Let It Go
Mon
23
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
University Health Service- Know Your Numbers
University Health Service- Mindful Eating
Tue
24
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK Elder Care Lunch & Learn - Don't Blame It On Aging
Ravi Zacharias at Memorial Coliseum
Wed
25
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
26
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Dimensions of Political Ecology Conference
Eday Talk by Georgetown Toyota President Wil James
Do What You Are: Connecting Personalities w/ Profession
Off- Campus Student Services' Wildcat Apartment Hop #3
Traditions and Transformations in Tz’utujil Territory, Lake Atitlan, Guatemala, 500 BC – 1524 AD
Concert in the Museum: Central Music Academy
Fri
27
Dimensions of Political Ecology Conference
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK E-Day
Pre-Opera Dinner
Sat
28
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
DanceBlue Rave Hour
Sun
29
Monday through Friday - Midterm Grading window is open. The mid-term grading window will close at midnight on March 11.
Monday through Wednesday - Students are prohibited from changing academic major
Bodies Of Evidence: Provocations: A Transnational Feminist History Project
Mon
 
 
 
 
 
Feb 12
Bill Adams: Blue Madness 02/12/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Mon Apr 04 2016 .
Sat, 02/13/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Apr 03 2016 .
Sat, 02/13/2016

Sat, 02/13/2016

Reset Page