Allison Elliott-Shannon

By

College: Medicine

Study Looks at Down Syndrome, Alzheimer’s

Published: Aug 29, 2011

LEXINGTON, Ky. (Aug. 29, 2011) — The following column appeared in the Lexington Herald-Leader on Sunday, Aug. 21. 

 

Study looks at Down syndrome, Alzheimer’s

SIGNS OF DISEASE SHOW UP AT YOUNGER AGES

 

By Dr. Elizabeth Head and Dr. Frederick Schmitt

Special to The Herald-Leader

 

Individuals with Down syndrome are living longer than ever, and they face increased risks of age-related conditions such as Alzheimer’s disease. In fact, due to an extra copy of a chromosome, people with Down syndrome produce extra Alzheimer’s-linked proteins in their brains.

 

Like all people with Alzheimer’s disease, people with Down syndrome develop plaques and tangles in their brains, but they do so at a younger age than people who don’t have Down syndrome.

 

Research has shown that virtually all individuals with Down syndrome have Alzheimer’s-like changes in their brains by age 40, although they might not develop dementia until age 50 or later.

 

During this approximately 10-year period, although the brain appears to have protein changes consistent with dementia, individuals continue to function at their usual levels.

 

This same thing occurs in the general population, as many participants in the UK Sanders-Brown Center on Aging brain donation program come to autopsy with full-blown Alzheimer’s pathology in their brains but no record of clinical dementia symptoms during life.

 

Working to understand how the brains of individuals with Down syndrome adapt to aging might hold keys to unraveling the mysteries of Alzheimer’s disease. If we as investigators learn how people can continue to function normally while their brains develop physical manifestations of Alzheimer’s, we might be one step closer to heading off dementia in millions of people.

 

Because the brain aging process is in many ways accelerated in people with Down syndrome, working with these individuals is an ideal way to study how we can prolong normal brain function for individuals with Down syndrome and the general population.

 

To this end, we are conducting a research study involving participants 35 and older who have Down syndrome. The study is funded by the National Institute of Child Health and Human Development. Participants are asked to come to the University of Kentucky every six months throughout the five-year study to give a blood sample, take thinking and memory tests, have a neurological exam, and undergo a MRI brain scan.

 

Our goal is to recruit and study 40 adults with Down syndrome who do not have signs of dementia, and 10 to 12 adults with Down syndrome who have been diagnosed with dementia. Those who already have dementia will come to UK only once.

 

While adults with Down syndrome are predisposed to Alzheimer’s disease, there is hope. We are learning much from their experiences and hope that our research will result in knowledge that can improve the quality of life for individuals with Down syndrome and their families, and for those with Alzheimer’s and related dementia.

 

For more information, go to www.uky.edu/dsaging, or call Roberta Davis at(859) 257-1412, Ext. 479.

 

Dr. Elizabeth Head and Dr. Frederick Schmitt are with the University of Kentucky Sanders-Brown Center on Aging.

e014998.jpg
March
1
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
2
Wildcat Wellness: Expressions (Creative Stress Relief)
Resume & Cover Letters that Work
Mon
3
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Grad Salute
2nd Annual UK Work-Life Summer Camps Fair
UK Elder Care Lunch & Learn - Keeping Your Brain Healthy
Successful Networking & Job Search
Guest Lecture
Documentary Screening: "Forgotten Wars, Forgotten Victims"
Bangladeshi Garment Worker Speak Out
A Reading by Nic Brown
CatWatch Party #3
Tue
4
LNFS Presents: The Mighty Ducks
Wildcat Wellness: Meditation
Internship Info Session
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Art Therapy Table
OUTspoken with J Mase III
CANCELED: Appalachian Forum with Crystal Wilkinson entitled: Birds of Opulence: Black Women, Madness, and Resilience in Appalachia
Wed
5
LNFS Presents: Typeface
LNFS Presents: Space Jam
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Food for Hope
Thu
6
LNFS Presents: A Girl Walks Home Alone at Night
LNFS Presents: Pokémon: The First Movie
Cultural Coffee Hour
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Japan Today
Fri
7
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Karnival Around The World
Graduate & Professional School Prep:KAPLAN Free Practice Test for MCAT and LSAT
PharmD Open House
Sat
8
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
9
Midterm of 2015 Spring Semester
Wildcat Wellness: Expressions (Creative Stress Relief)
GUEST LECTURE
Appalachian Forum with Rebecca Klenk, Topic: Global Uttarakhand: Development, Neoliberalism and Social Justice in Himalayan India
Ballroom Thieves
Mon
10
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: Staying Positive During A Job Search
Massage on the Go #2
Tue
11
LNFS Presents: Only Lovers Left Alive
Wildcat Wellness: Meditation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Jin Shin Jyutsu Self-Help Class
Leadership Assessment
#TrendingTopics: Immunization
True Songs
Wed
12
LNFS Presents: Into the Woods
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Free Spring Break Shuttle to Blue Grass Airport
LNFS Presents: Waiting for 'Superman'
Thu
13
LNFS Presents: Vertigo
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Free Spring Break Shuttle to Blue Grass Airport
LNFS Presents: Trainspotting
Fri
14
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
15
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
16
Spring 2015 Spring Vacation
Mon
17
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Tue
18
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wed
19
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Thu
20
Spring 2015 Spring Vacation
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Plating Design Demonstration with Dan Wu
Fri
21
Spring 2015 Spring Vacation
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
22
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
23
Wildcat Wellness: Expressions (Creative Stress Relief)
"Thrive: The Kentucky Wine Tradition" Documentary Screening
Mon
24
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: A Snapshot of the Central Kentucky Labor Market
Career & Major Exploration Session @ 1 p.m.
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Kentucky Teacher's Network Career Fair
Tue
25
LNFS Presents: Rear Window
Wildcat Wellness: Meditation
Internship Info Session
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Healthy Smoothie Demonstration
Cultural Diversity Festival: Ten Thousand Villages
Virtual Dementia Tour
Career & Major Exploration Session @ 1 p.m.
Healthy Smoothie Demonstration
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Barred for Life: A Conversation on Mass Incarceration
Women of the World: Rosario Dawson
Wed
26
LNFS Presents: The Imitation Game
LNFS Presents: Blade Runner
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Student & Employer Mixer
Young Artists Exhibit Reception
Thu
27
LNFS Presents: Psycho
LNFS Presents: The Life Aquatic with Steve Zissou
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
UK Woman's Club Craft and Bake Sale
Northeast Florida’s Late Archaic Mortuary Mounds: Memory, Community, and Environment.
Fri
28
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
29
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Lion King Trip
The Voice of Lexington Chinese Singing Competetion
Sun
30
Wildcat Wellness: Expressions (Creative Stress Relief)
Mon
31
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
A Reading by Jim Gavin
Tue
 
 
 
 
Mar 31
Wildcat Wellness: Relaxation 03/31/2015

Tue, 03/31/2015

Wed, 04/01/2015

Repeats every week until Thu Apr 30 2015 except Wed Mar 18 2015.
Wed, 04/01/2015

Repeats every week until Wed May 06 2015 except Wed Mar 18 2015.
Wed, 04/01/2015

Reset Page