Allison Elliott-Shannon

By

College: Public Health

$3 Million NIA Grant Awarded to SBCoA to Create Multicenter Alzheimer's Database

Published: Nov 22, 2011

 

 

LEXINGTON, Ky. (Nov. 22, 2011) — University of Kentucky Sanders-Brown Center on Aging (SBCoA) researchers, led by co-principal investigators Richard Kryscio and Frederick Schmitt, have been awarded a grant of more than $3 million from the National Institute on Aging, to identify risk factors for multiple forms of autopsy-confirmed dementia.

 

Kryscio, who also serves as chair of the Department of Biostatistics in the UK College of Public Health, and Schmitt, who serves as a professor in the Department of Neurology in the UK College of Medicine, will collaborate with fellow SBCoA investigators Erin Abner, David Fardo, Greg Jicha, Peter Nelson, and Stephen Scheff to conduct a large-scale study that will merge data from seven existing databases.

 

In diseases like Alzheimer's, there is a continuum of illness that ranges from asymptomatic (normal cognition) to full dementia. The aim of the project will be to study large data sets collected over many years by Alzheimer's Disease Centers and population-based research projects around the country. Each included project has its own set of longitudinal data on individuals who have transitioned from normal cognition, through mild cognitive impairment, and into dementia. Many of these individuals died and came to autopsy, the gold standard in the diagnosis of most forms of dementia. Merging these data will allow rigorous, statistical, and biologically-informed analyses.

 

The project will draw on the expertise of a neuroepidemiologist (Suzanne Tyas, University of Waterloo), and the study data will be drawn from seven projects: BRAiNS (University of Kentucky SBCoA), the Nun Study (University of Minnesota, Kelvin Limm and Laura Hemmy P.I.), the Memory and Aging Project (Washington University; Chengjie Xiong, P.I.), the  Honolulu-Asia Aging Study (Kuakini Medical Center Hospital; Lon White, P.I.), the Religious Orders Study (Rush Medical University; Lei Yu and David Bennett, P.I.), Oregon Brain Aging Study and others (Oregon Health and Science University; Jeffrey Kaye and Hiroko Dodge, P.I.), and the Einstein Aging Study (Einstein Medical College, Richard Lipton, P.I.).

 

Once the data are assembled into one overarching database, Kryscio, Schmitt, and their team will identify appropriate intervening states between normal cognition and dementia based on periodic assessments of cognition and functional skills from data collected at the involved centers. A focus will be on transitions into rare and mixed dementias, which has previously been impossible due to the small number of cases seen within individual studies. Ultimately, the standardization and subsequent analysis of data across studies could reveal new ways of understanding mixed forms of dementia, and may provide clinicians with new diagnostic criteria to use when working with patients who have either dementia or preclinical dementia conditions.

 

“This grant application by Drs. Kryscio and Schmitt received an amazing, perfect score from the review panel, which emphasizes the highly significant and innovative nature of this project,” said Linda Van Eldik, director of the SBCoA and the Alzheimer’s Disease Center at UK.

0230.jpeg
September
 
1
Employee Educational Assistance Award
Labor Day - Academic Holiday
Mon
2
Employee Educational Assistance Award
Internship Info Session
Student/Faculty/Staff Mixer
Tue
3
Employee Educational Assistance Award
LNFS Presents: The Wolf of Wall Street
Last Day to Add a Class
Last Day to Drop a Course with 80% Refund
UK Volunteer Fair
Wed
4
LNFS Presents: Children of Men
LNFS Presents: How To Train Your Dragon 2
Black and Latino Male Initiative
Advance Your Swagger: A Night with Fonzworth Bentely
Thu
5
Kentucky Volleyball vs. Northern Iowa
Kentucky Volleyball vs. USC
LNFS Presents: Spirited Away
LNFS Presents: Mulan
Fri
6
Free Saturday Swing Dance Lessons
Kentucky Football vs. Ohio
#maxfest (Ukirklex Campus Ministry)
Kentucky Volleyball vs. Creighton
Lets Swing Dance!
Sat
7
Kentucky Women's Soccer vs. Morehead State
Sun
8
Diversity Organization's Council
Kosher/Soul? (Jewish, African American & Appalachian culture Fuse)
Mon
9
Working Moms Connection
Job Club - Job Search Strategies for Fall
Rock Star Professionalism Series
Tue
10
Massage on the Go
College: Do the Right Thing- A conversation with Dr. Smith
The Future of Islam
LNFS Presents: Fight Club
Wed
11
9/11 Vigil
UKNABJ presents: Ferguson, Missouri: A look at media, politics and black youth in the U.S.
LNFS Presents: Mr & Mrs Smith
Duo Damiana, Molly Barth and Dieter Hennings
LNFS Presents: 22 Jump Street
Thu
12
LNFS Presents: Searching For Sugarman
LNFS Presents: Sin City
Fri
13
Free Saturday Swing Dance Lessons
Men's Soccer vs. ETSU
Sat
14
Kentucky Women's Soccer vs. Pepperdine
Sun
15
Kentucky Week Farmer's MarCat and Craft Fair
Majestic U.N.I.T.Y.
Mon
16
Justice Delayed not Justice Denied: A Talk with Dough Jones
PRHBTN Gallery Reception and Concert
Men's Soccer vs. Xavier
Chellgren Seminar Series: Buck Ryan
Tue
17
Internship Info Session
Last Day to Drop a Course Without Appearing on Transcript
Caregiver Support Group
LNFS Presents: The Immigrant
Big Blue Commonwealth
Wed
18
LNFS Presents: Watermark
LNFS Presents: X-Men: Days of Future Past
Ryan Gardner Guest Trumpet Recital
Kentucky Volleyball vs. Lipscomb
Thu
19
LNFS Presents: A Band Called Death
LNFS Presents: Prisoners
The Case for Fossil Fuels-PEIK Seminar
Men's Soccer vs. Furman
Fri
20
Rock Climbing @ Red River Gorge
College of Pharmacy Open House
Kentucky Volleyball vs. Xavier
Sat
21
 
Sun
22
Diana Ferrus: 'Writing poetry has allowed me to live': Cultural Resistance in South Africa
Kentucky Law Schools Forum
Mon
23
Pinterest Party
University of Kentucky Chamber Winds
Employer Showcase
Job Club - 10 Questions to Ask Prior to Starting a Business
Men's Soccer vs. Lousville
Tue
24
Employer Showcase
Last Day to Drop a Course with 50% Refund
UK Elder Care Lunch & Learn
BPH Open House
Documentary Film Screening - Heaven + Earth + Joe Davis
LNFS Presents: Saving Mr. Banks
Wed
25
LNFS Presents: Culture Jam
LNFS Presents: Maleficent
¡Baila!
Thu
26
LNFS Presents: Ponyo
LNFS Presents: The Little Mermaid
Opening Night Bohemiam Festival
White Water Rafting @ Chattooga River
Women's Soccer vs. Mississippi State
Fri
27
White Water Rafting @ Chattooga River
Kentucky Football vs. Vanderbilt
Free Saturday Swing Dance Lessons
Green Apple Day of Service: "Pick It Up"
Swing Dancing!
Sat
28
White Water Rafting @ Chattooga River
UK Chorale
Dirty Dancing Trip
Kentucky Women's Soccer vs. Auburn
Sun
29
 
Mon
30
#TrendingTopics: Immigration Reform
Apollo Duo - Flute and Percussion Guest Recital
Tue
 
 
 
 
Reset Page