Allison Elliott-Shannon

By

College: Medicine

A Genetic Answer to the Alzheimer's Riddle?

Published: Aug 14, 2013

LEXINGTON, Ky. (Aug. 14, 2013) — What if we could pinpoint a hereditary cause for

Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer's genetics; the research is detailed in a paper published today in the Journal of Neuroscience.

 

Emerging evidence indicates that, much like in the case of high cholesterol, some Alzheimer's disease risk is inherited while the remainder is environmental. Family and twin studies suggest that about 70 percent of total Alzheimer's risk is hereditary.

 

Recently published studies identified several variations in DNA sequence that each modify Alzheimer's risk. In their work, the UK researchers investigated how one of these sequence variations may act. They found that a "protective" genetic variation near a gene called CD33 correlated strongly with how the CD33 mRNA was assembled in the human brain. The authors found that a form of CD33 that lacked a critical functional domain correlates with reduced risk of Alzheimers disease. CD33 is thought to inhibit clearance of amyloid beta, a hallmark of Alzheimers disease.

 

The results obtained by the UK scientists indicate that inhibiting CD33 may reduce Alzheimer's risk. A drug tested for acute myeloid leukemia targets CD33, suggesting the potential for treatments based on CD33 to mitigate the risk for Alzheimer's disease.  Additional studies must be conducted before this treatment approach could be tested in humans.

 

Authors on the paper, titled "CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing" are Manasi Malik (lead author), Steven Estus, James F. Simpson, and Ishiti Parikh, all of the UK Department of Physiology; Bernard R. Wilfred and Peter Nelson of the UK Department of Pathology, and David W. Fardo of the UK Department of Biostatistics.

 

MEDIA CONTACT: Allison Elliott-Shannon, allison.elliott@uky.edu

 

 

 

 

109222821.jpg
August
 
1
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Mon
2
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Tue
3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Wed
4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
End of the Summer II 2016 Eight-Week Session
Thu
5
 
Fri
6
 
Sat
7
 
Sun
8
 
Mon
9
 
Tue
10
 
Wed
11
 
Thu
12
 
Fri
13
Parent and Families Open House
Sat
14
 
Sun
15
 
Mon
16
UK Women's Forum Board Meeting
Tue
17
 
Wed
18
 
Thu
19
K Week Kick-off
Off-campus Freshmen Check-in
Parent and Families Reception
Fri
20
New Student Induction Ceremony
Big Blue U
Getting Around Campus and Beyond
Campus Ruckus
Sat
21
UK Lex-Mart
K Team Lunch
Late-night Target Run
Sun
22
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Dinner with your K Team
Mon
23
We Are UK
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Campus Tours for K Teams
Tue
24
First Day of School Photos
First day of classes of Fall 2016
Wed
25
Pedalpalooza
First Day of School Photos
Thu
26
OCSS Wildcat Block Watch
Fri
27
Louis Zoellar Bickett: Saving Myself
Red River Gorge Adventure Trip for Out-of-State Students
Music Workshop for Teachers and Students: Michael Chandler
Flight 5191 Tenth Anniversary Memorial Service
Sat
28
Louis Zoellar Bickett: Saving Myself
Sun
29
Louis Zoellar Bickett: Saving Myself
Mon
30
Louis Zoellar Bickett: Saving Myself
Last Day to Add a Class for Fall 2016
Last Day to Withdraw to Receive 80% Refund
Tue
31
Louis Zoellar Bickett: Saving Myself
Wed
 
 
 
Reset Page