Allison Elliott-Shannon

By

College: Medicine

A Genetic Answer to the Alzheimer's Riddle?

Published: Aug 14, 2013

LEXINGTON, Ky. (Aug. 14, 2013) — What if we could pinpoint a hereditary cause for

Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer's genetics; the research is detailed in a paper published today in the Journal of Neuroscience.

 

Emerging evidence indicates that, much like in the case of high cholesterol, some Alzheimer's disease risk is inherited while the remainder is environmental. Family and twin studies suggest that about 70 percent of total Alzheimer's risk is hereditary.

 

Recently published studies identified several variations in DNA sequence that each modify Alzheimer's risk. In their work, the UK researchers investigated how one of these sequence variations may act. They found that a "protective" genetic variation near a gene called CD33 correlated strongly with how the CD33 mRNA was assembled in the human brain. The authors found that a form of CD33 that lacked a critical functional domain correlates with reduced risk of Alzheimers disease. CD33 is thought to inhibit clearance of amyloid beta, a hallmark of Alzheimers disease.

 

The results obtained by the UK scientists indicate that inhibiting CD33 may reduce Alzheimer's risk. A drug tested for acute myeloid leukemia targets CD33, suggesting the potential for treatments based on CD33 to mitigate the risk for Alzheimer's disease.  Additional studies must be conducted before this treatment approach could be tested in humans.

 

Authors on the paper, titled "CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing" are Manasi Malik (lead author), Steven Estus, James F. Simpson, and Ishiti Parikh, all of the UK Department of Physiology; Bernard R. Wilfred and Peter Nelson of the UK Department of Pathology, and David W. Fardo of the UK Department of Biostatistics.

 

MEDIA CONTACT: Allison Elliott-Shannon, allison.elliott@uky.edu

 

 

 

 

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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Healthy Smoothie Demonstration
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
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Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
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Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Vivian Maier: On the Street
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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27
Healthy Smoothie Demonstration
Healthy Smoothie Demonstration
Healthy Smoothie Demonstration
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Wed
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Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Thu
29
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Fri
30
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Family Say at the Art Museum
Sat
31
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Sun
 
 
 
 
 
 

Repeats every day on May, June, July every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Jul 26 2015 .
Sat, 05/30/2015

Sat, 05/30/2015

Repeats every day on May, June, July every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Jul 26 2015 .
Sun, 05/31/2015

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