Keith Hautala

By

College: Medicine

Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures

Published: Apr 22, 2014

 

LEXINGTON, Ky. (April 22, 2014) — A team of nanotechnology researchers at the University of Kentucky has discovered new methods to build heat resistant nanostructures and arrays using RNA. 

 

The research, led by Peixuan Guo, professor and  William Farish Endowed Chair in Nanobiotechnology at the UK College of Pharmacy and Markey Cancer Center, is reported in an article titled "RNA as a Boiling-Resistant Anionic Polymer Material To Build Robust Structures with Defined Shape and Stoichiometry," coauthored by Emil F. Khisamutdinov and Daniel L. Jasinski.

 

The article, which will appear in a forthcoming edition of the journal ACS Nano, published by the American Chemical Society (ACS), was selected as an ACS "Editors’ Choice" and prepublication data is available for free download as a PDF through open access at http://dx.doi.org/10.1021/nn5006254.

 

Chemical polymers have seen extensive use in a variety of industries — including clothing, piping, plastics, containers, bottles, cookware, tools and medical materials for drug delivery and tissue engineer materials — because of their high stability and ability to hold their global shape and size. However, on the microscopic scale, these polymers form into random micro-structures, making their size and shape difficult to control. 

 

The Guo lab reports that RNA (ribonucleic acid) can be used as an anionic polymer material to build nanostructures with controllable shape and defined structure. The researchers have fabricated a new RNA triangle structure that utilizes RNA’s intrinsic control over shape and size on the nano scale, while demonstrating strong stability.

 

Previously, RNA was seen as structurally fragile and easily dissociable at a range of temperatures from 35-70 degrees Celsius, making its application feasibility in an industrial setting very limited. Using the special RNA motif discovered in Guo's lab and a new methodology, the researchers demonstrated that they can build RNA nanostructures and patterned arrays that are resistant to 100 degrees Celsius, the boiling temperature of water.

 

The new RNA triangular nanoarchitechtures can be used to form arrays with a controllable repeat number of the scaffold, resembling monomer units in a polymerization reaction. Thus, the Guo lab was able to produce a honeycomb RNA structure with the new RNAs, allowing for the production of RNA sheets.

 

Experts say this breakthrough pushes the field of RNA nanotechnology forward, positioning RNA to be a new, unique type of polymer with advantages over conventional chemical polymers.

 

"This research shows great potential for building stable RNA nanoparticles with properties that could be more easily controlled than standard polymers," said Jessica Tucker, National Institute of Biomedical Imaging and Bioengineering program director for drug and gene delivery systems and devices. "The more control we have over the nanoparticles, the better we can tailor them for use in therapeutics for diseases ranging from cancer to diabetes."

 

The research was supported by National Institute of Biomedical Imaging and Bioengineering AND National Cancer Institute grants NIBIB EB003730 and NCI CA151648.  

guo.jpg
December
 
1
Resumes and Cover Letters
Circle of Love Gift Return
Mon
2
UK Guitar Studio
Circle of Love Gift Return
Tue
3
Networking and Job Search
Internship Info Session
LNFS Presents: Wayne's World
Study Sounds: Classical Concert
Wed
4
LNFS Presents: Frozen
Ballet Music of Tchaikovsky
Circle of Love Gift Pick-Up
Live Screening of Orion Spacecraft Re-entry
Massage on the Go
Thu
5
LNFS Presents: Winter's Bone
LNFS Presents: Gremlins
Open Studio
Circle of Love Gift Pick-Up
Fri
6
Snow Skiing @ Perfect North Slopes
Sat
7
Free Holiday Shopping Shuttle to Fayette Mall
Sun
8
Undergraduate Research Information Session "How to Find a Faculty Mentor"
Mon
9
Job Club - Identifying Your Skills
Paws for Stress Relief
Tue
10
 
Wed
11
 
Thu
12
Last Day of Classes
Fri
13
 
Sat
14
Free Holiday Shopping Shuttle to Fayette Mall
Finals Treats
Sun
15
Final Exams
Crunch Brunch
Mon
16
Final Exams
Jazzy Holiday Concert
Tue
17
Final Exams
Caregiver Support Group
Wed
18
Final Exams
Thu
19
Final Exams
End of 2014 Fall Semester
Fri
20
 
Sat
21
 
Sun
22
 
Mon
23
 
Tue
24
 
Wed
25
 
Thu
26
 
Fri
27
 
Sat
28
 
Sun
29
 
Mon
30
 
Tue
31
 
Wed
 
 
 
Jan 14
Bicycle Trivia 01/14/2015

Wed, 01/14/2015

Fri, 01/16/2015

Wed, 01/21/2015

Reset Page