Allison Perry

Markey Researchers Develop Web-Based App to Predict Glioma Mutations

Published: Aug 19, 2014

LEXINGTON, Ky. (Aug. 19, 2014) – A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation.

 

Gliomas – a type of tumor that begins in the brain or spine – are the most common and deadly form of brain cancer in adults, making up about 80 percent of malignant brain cancer cases. In some of these cases, patients have a mutation in a specific gene, known as an IDH1 mutation – and patients who have this tend to survive years longer than those who do not carry the mutation.

 

Developed by UK researchers Li Chen, Eric Durbin, and Craig Horbinski in collaboration with software architect Isaac Hands of the UK Markey Cancer Center Cancer Research Informatics Shared Research Facility, the program uses a statistical model to accurately predict the likelihood that a patient carries the IDH1 mutation and requires screening.

 

Gliomas are often tested for IDH1 mutation following surgery to remove the tumor, but undergoing this type of testing often requires stringent insurance pre-approvals due to rising healthcare costs, Horbinski says.

 

"Currently, there are no universally accepted guidelines for when gliomas should be tested for this mutation," Horbinski said. "Obtaining insurance pre-approval for additional molecular testing is becoming more commonplace, and this program will assist healthcare providers with an evidence-based rationale for when IDH1 screening is necessary."

 

Additionally, Horbinski notes that the program will help conserve research dollars by helping brain cancer researchers narrow down which specific older gliomas in tumor banks – previously removed in a time before IDH1 testing was routine – should be tested as data for research projects.

 

Horbinski's research on the program was published in the May issue of Neuro-Oncology. The work was funded through a grant from the National Cancer Institute, the Peter and Carmen Lucia Buck Training Program in Translational Clinical Oncology, and the University of Kentucky College of Medicine Physician Scientist Program.

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

screen_shot_2014-08-18_at_4.41.45_pm.png
August
 
1
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Mon
2
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Tue
3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Wed
4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
End of the Summer II 2016 Eight-Week Session
Thu
5
 
Fri
6
 
Sat
7
 
Sun
8
 
Mon
9
 
Tue
10
 
Wed
11
 
Thu
12
 
Fri
13
Parent and Families Open House
Sat
14
 
Sun
15
 
Mon
16
UK Women's Forum Board Meeting
Tue
17
 
Wed
18
 
Thu
19
K Week Kick-off
Off-campus Freshmen Check-in
Parent and Families Reception
Fri
20
New Student Induction Ceremony
Big Blue U
Getting Around Campus and Beyond
Campus Ruckus
Sat
21
UK Lex-Mart
K Team Lunch
Late-night Target Run
Sun
22
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Dinner with your K Team
Mon
23
We Are UK
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Campus Tours for K Teams
Tue
24
First Day of School Photos
First day of classes of Fall 2016
Wed
25
Pedalpalooza
First Day of School Photos
Thu
26
OCSS Wildcat Block Watch
Fri
27
Louis Zoellar Bickett: Saving Myself
Red River Gorge Adventure Trip for Out-of-State Students
Music Workshop for Teachers and Students: Michael Chandler
Flight 5191 Tenth Anniversary Memorial Service
Sat
28
Louis Zoellar Bickett: Saving Myself
Sun
29
Louis Zoellar Bickett: Saving Myself
Mon
30
Louis Zoellar Bickett: Saving Myself
Last Day to Add a Class for Fall 2016
Last Day to Withdraw to Receive 80% Refund
Tue
31
Louis Zoellar Bickett: Saving Myself
Wed
 
 
 
Aug 26
OCSS Wildcat Block Watch 08/26/2016

Fri, 08/26/2016

Sat, 08/27/2016 - Sun, 11/27/2016

Reset Page