Allison Elliott-Shannon

By

College: Medicine

New Research Focuses on Prion Diseases

Published: Mar 14, 2011

LEXINGTON, Ky. (March 14, 2011) — New research by Chongsuk Ryou, researcher at the UK Sanders-Brown Center on Aging and professor of microbiology, immunology and molecular genetics in the UK College of Medicine, may shed light on possible treatments for prion diseases.
 

Prion diseases, which include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy ("mad cow" disease) in cattle, are caused by prions — unconventional pathogens composed of infectious protein particles and resistant to conventional sterilization procedures. Presently there is no known agent or procedure that can halt or reverse damage caused by prion disease.

Ryou and colleagues, however, have demonstrated through recent work that polymers of amino acid lysine (polylysines) are able to block propagation of prions by targeting plasminogen - a substance that stimulates the multiplication of prions. In test tubes and cultured cells, polylysines halted the spread of prions.
 

Furthermore, in an animal model of prion disease, mice treated with polylysines displayed symptoms later, survived longer and showed lower levels of prions in their brains than did untreated mice.
 

"Our study suggests that polylysine is a potential anti-prion agent and validates plasminogen as a therapeutic target to combat prion disease," said Ryou.
 

Ryou's research appears in the latest issue of the journal Biomaterials.

MEDIA CONTACT: Allison Elliott, allison.elliott@uky.edu

 

prion.jpg
October
 
 
 
 
 
 
1
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sat
2
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sun
3
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Empower: People of Color Support Group
Empower: People of Color Support Group
Mon
4
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Wildcat Wellness Workshop: EXPRESSIONS
Wildcat Wellness Workshop: EXPRESSIONS
Wildcat Wellness Workshop: EXPRESSIONS
Wildcat Wellness Workshop: EXPRESSIONS
Wildcat Wellness Workshop: EXPRESSIONS
Homecoming Royalty Programing
Flu Shots
Tue
5
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: MEDITATION
Wildcat Wellness Workshop: MEDITATION
Wildcat Wellness Workshop: MEDITATION
Wildcat Wellness Workshop: MEDITATION
Wildcat Wellness Workshop: MEDITATION
Horticulture Club Farm Market Sale
Horticulture Club Farm Market Sale
Horticulture Club Farm Market Sale
Free HIV Screenings! #UKGYT
Wed
6
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: YOGA
Wildcat Wellness Workshop: YOGA
Wildcat Wellness Workshop: YOGA
Wildcat Wellness Workshop: YOGA
Wildcat Wellness Workshop: YOGA
OCSS Off-Campus Housing Fair
Flu Shots
Street Fair
Thu
7
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Family Weekend: James W. Stuckert Career Center Open House
Family Weekend Check-In and Resource Fair
Family Weekend: MacAdam Student Observatory
Fri
8
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Family Weekend Tent Party
Keeneland Breakfast with the Works & Out-of State Family Meet-and-Greet
Sat
9
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Family Weekend DNT 101: A Taste of the Kentucky Doughnut Trail
Family Weekend: See the Sun!
Family Weekend: Sunday Lunch at Historic Spindletop Hall
Sun
10
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Empower: People of Color Support Group
Mon
11
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Wildcat Wellness Workshop: EXPRESSIONS
UK Elder Care Lunch & Learn - Why Pre-Planning Is So Important
Tue
12
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: MEDITATION
NSE (National Student Exchange) Information Session
Flu Shots
Wed
13
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: YOGA
Thu
14
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Black and Blue: Critical Issues on Race and Policing in the US
Fri
15
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sat
16
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sun
17
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Midterm of Fall 2016
Let's Talk!
Empower: People of Color Support Group
Mon
18
Louis Zoellar Bickett: Saving Myself
Let's Talk!
UK Women's Forum Board Meeting
Wildcat Wellness Workshop: EXPRESSIONS
Flu Shots
Tue
19
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: MEDITATION
Flu Shots
Wed
20
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Media and Diversity TED Talk
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: YOGA
Thu
21
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Fri
22
Louis Zoellar Bickett: Saving Myself
Let's Talk!
UK Woman's Club Fund Run
Sat
23
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sun
24
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Empower: People of Color Support Group
Mon
25
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Wildcat Wellness Workshop: EXPRESSIONS
Tue
26
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: MEDITATION
NSE (National Student Exchange) info session
Kentucky Statewide Trauma and Emergency Medicine Symposium
Flu Shots
Wed
27
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Kentucky Statewide Trauma and Emergency Medicine Symposium
Let's Talk!
Let's Talk!
Wildcat Wellness Workshop: YOGA
Thu
28
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Kentucky Statewide Trauma and Emergency Medicine Symposium
Fri
29
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sat
30
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Sun
31
Louis Zoellar Bickett: Saving Myself
Let's Talk!
Let's Talk!
Empower: People of Color Support Group
Mon
 
 
 
 
 
Oct 03
Let's Talk! 10/03/2016

Repeats every 7 days until Tue Dec 20 2016 .
Mon, 10/03/2016

Repeats every week until Mon Dec 05 2016 .
Mon, 10/03/2016

Repeats every 7 days until Tue Dec 13 2016 .
Tue, 10/04/2016

Tue, 10/04/2016

Reset Page