Allison Perry

By

College: Arts and Sciences

New Ruthenium-based Drugs Show Promise for Killing Cancer Cells

Published: Jun 8, 2012

LEXINGTON, Ky. (June 8, 2012) — A new study by University of Kentucky researchers shows how light and strained ruthenium-based drugs may be more effective at fighting cancer cells and less toxic to healthy cells than a similar and widely used drug.

 

Cisplatin is a common platinum-based cancer drug. But while cisplatin kills cancer cells, it also attacks healthy cells, causing debilitating side effects. Ruthenium is a rare transition metal also belonging to the platinum group of the periodic table, and the UK researchers developed two new ruthenium complexes designed to kill cancer cells while preserving healthy cells.

 

These complexes are inert in the dark, but when activated with light, they become up to 200 times as toxic, and up to three times as potent as cisplatin against tumor cells.

 

Published in the Journal of the American Chemical Society, the study examined the effects of these new complexes on lung cancer and leukemia cells. Edith Glazer, UK assistant professor of chemistry and principal investigator for the study, hopes to move these compounds forward in more biological testing soon.

 

"Coordination chemistry has proven to be an elegant method to rapidly synthesize a family of molecules," Glazer said. "We anticipate that this will prove advantageous in allowing us to make chemical modifications to optimize properties as needed as we move forward into animal studies."

 

 

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu.

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Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
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Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
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UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
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3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
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4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Independence Day - Academic Holiday
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
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Mon
5
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
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6
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
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7
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
8
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
9
UK Writing Center Open for Summer Session 2 (June 9-August 4)
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Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
10
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
11
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
12
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
13
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Birdhouse Display and Auction
Wed
14
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
15
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Curator Tour
Fri
16
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
17
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
18
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
19
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
UK Women's Forum Board Meeting
Tue
20
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
21
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
22
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
23
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
24
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
25
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
26
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
27
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
28
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
29
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
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30
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
31
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
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