UKNOW University of Kentucky News

Novel Drug Shown to Slow Breast Cancer Growth Available in Markey Clinical Trial

Published: Jan 6, 2012

LEXINGTON, Ky. (Jan. 6, 2012) — A new drug that could slow breast cancer metastasis by several months is currently available in a clinical trial at the University of Kentucky Markey Cancer Center.

The novel agent, everolimus/RAD001 (BOLERO-2), was given in conjunction with exemestane, a hormone therapy treatment that deprives tumors of estrogen to slow their growth. Everolimus works by inhibiting mTOR, a protein that often spurs tumor growth after tumors become resistant to hormone therapy.

The BOLERO-2 trial, presented this month at the San Antonio Breast Symposium, and published in the New England Journal of Medicine, showed that women who took both everolimus and exemestane had a median progression-free survival of almost 11 months compared with about four months for those who took a placebo plus exemestane.

Though everolimus isn't ready for widespread use yet — it needs FDA approval first— it is available as part of a clinical trial at the UK Markey Cancer Center for women with hormone receptor positive metastatic breast cancer that has not responded to aromatase inhibitor therapy. The Markey trial combines everolimus with fulvestrant, another form of antiestrogen treatment.

Breast oncologist Dr. Suleiman Massarweh is the principal investigator for the project. The use of everolimus in conjunction with hormone therapy has been a major part of his work on endocrine therapy resistance for years now.

"This is an exciting time for novel therapies in hormone positive breast cancer, an area that has been my focus of research for 10 years,” Massarweh said. "It is gratifying to see this field grow and impact patient care, and for us to be at the forefront of this research."

For more information on this clinical trial, patients or physicans can contact Massarweh directly at massarweh@uky.edu or (859) 257-3608. For more information on other clinical trials at the UK Markey Cancer Center, visit the Markey website.

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

Tags:

+/- Move

Most Popular Articles

"see service." UK Graduate Makes Impact on Campus & Community

05/07/2012 - 1:51pm

Dean Tim Tracy to Serve as Interim Provost

04/30/2012 - 6:46pm

Fun Day Slated for May 17 for Employees and Their Families

05/15/2012 - 11:31am

Celebrating Our Newest Alumni – UK's 145th Commencement Ceremonies

04/25/2012 - 6:01pm

Improving Mental Health Through Supported Employment

05/11/2012 - 4:01am

- +

+/- Move

Most Recent Articles

DOE Highlights UK Design's Plan for Paducah Gaseous Diffusion Plant

05/18/2012 - 12:26pm

UK College of Health Sciences Inducts Alumni Into Hall of Fame

05/17/2012 - 4:41pm

Duke Ellington Jazz Series Returns to Lyric

05/18/2012 - 4:01am

UK Theatre Prof Brings to Life Unheard African Voices in National Project

05/18/2012 - 11:30am

College of Engineering Signs Agreement with Somerset Community College

05/18/2012 - 4:01am

- +

+/- Move

List view Calendar view

Campus Calendar

May
		1 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Student-Teacher-Student Exhibit view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Ovid's Cafe Open for Finals view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Fine Arts Institute Classes & Workshops view Academic Calendar: Eight-Week Summer Session registration and add/drop continues for students enrolled in the 2012 Spring Semester view Academic Calendar: Add/Drop for priority registered students for the 2012 Fall Semester view Academic Calendar: First summer session registration and add/drop continue for students enrolled in the 2012 Spring Semester view Academic Calendar: Eight-Week Second Summer Session registration and add/drop continue for students enrolled in the 2012 Spring Semester view Tue	2 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Student-Teacher-Student Exhibit view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Ovid's Cafe Open for Finals view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Free Parking for South Campus Residence Hall Move Out view Systems Thinking For Sustainability Student Showcase view Wed	3 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Ovid's Cafe Open for Finals view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Free Parking for South Campus Residence Hall Move Out view UK Employee Benefits Open Enrollment view Student-Teacher-Student Exhibit view From Street to Studio view Thu	4 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Ovid's Cafe Open for Finals view Free Parking for South Campus Residence Hall Move Out view Academic Calendar: Last day for candidates for a May degree to submit a thesis/dissertation to The Graduate School view Fri	5 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view SPUR meeting view Sat
6 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view 145th Commencement view Sun	7 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Dodgeball Open Gym view Academic Calendar: Beginning of College of Pharmacy 15-Week Summer Term view Academic Calendar: Advising Conference and Registration for new and readmitted students view Academic Calendar: Deadline for applying for admission to the Graduate School for the 2012 Eight-Week Summer Session view Academic Calendar: Deadline for applying for admission to the Graduate School for the 2012 Eight-Week Second Summer Session view OpenClass Experiences: Presentations and Discussions view American Red Cross Lifeguarding Course view Mon	8 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course view UK Employee Benefits Open Enrollment view Academic Calendar: Last day a student may officially drop a course or cancel registration with the University Registrar for a full refund of fees view Academic Calendar: First day of Four-Week First Summer classes view Academic Calendar: Late registration for returning students not already registered and new applicants cleared late for admission. view Tue	9 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Academic Calendar: Last day to add a class for the 2012 First summer session view Academic Calendar: Last day to officially withdraw from the University or reduce course load and receive an 80 percent refund view Academic Calendar: Last day for students in the Employee Educational Program to submit EEP form to Human Resource Services for tuition waiver for the 2012 First summer session view Wed	10 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Staff Senate Meeting view Adobe Day on Campus view Thu	11 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Fri	12 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view SPUR meeting view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course #9 view Sat
13 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view American Red Cross Lifeguarding Course #9 view Sun	14 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Academic Calendar: Last day to drop a course without it appearing on the student's transcript view Academic Calendar: Last day to change a grading option view Mon	15 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Academic Calendar: Last day to officially withdraw from the University or reduce course load and receive a 50 percent refund view Academic Calendar: Final deadline for submission of application and all required documents to the Office of Admissions for undergraduate admission for the 2012 Eight-Week Summer Session view Tue	16 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view UK Employee Benefits Open Enrollment view Academic Calendar: Second summer session registration and add/drop for students who entered the University in the 2012 first summer session view Academic Calendar: Eight-Week registration and add/drop for students who entered the University in the 2012 Four-Week Intersession view Wed	17 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view UK Employee Benefits Open Enrollment view The 31st Annual UK Symposium in Reproductive Science & Women’s Health view UK Fun Day view Thu	18 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view The 31st Annual UK Symposium in Reproductive Science & Women’s Health view American Red Cross Lifeguarding Course #9 view Fri	19 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view American Red Cross Lifeguarding Course #9 view Sat
20 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view American Red Cross Lifeguarding Course #9 view 43rd Annual Family Medicine Review Session 2 view Sun	21 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Academic Calendar: Midterm of 2012 Four-Week Intersession view 43rd Annual Family Medicine Review Session 2 view Mon	22 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Academic Calendar: Payment deadline of registration fees and/or housing and dining fees view 43rd Annual Family Medicine Review Session 2 view Tue	23 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Academic Calendar: Last day to withdraw from the University or reduce course load view 43rd Annual Family Medicine Review Session 2 view Lexington Farmers Market @ UK view Wed	24 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view 43rd Annual Family Medicine Review Session 2 view Thu	25 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view 43rd Annual Family Medicine Review Session 2 view Fri	26 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Sat
27 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Sun	28 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view Academic Calendar: Memorial Day - Academic Holiday view Academic Calendar: Final grading window is open view Mon	29 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view American Red Cross Lifeguarding Course #10 view Tue	30 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view American Red Cross Lifeguarding Course #10 view Academic Calendar: Last day for doctoral candidates for an August degree to submit a Notification of Intent to schedule a final examination in The Graduate School 2012 Four-Week - First Summer Session view Academic Calendar: Last day for doctoral candidates for an August degree to submit a Notification of Intent to schedule a final examination in The Graduate School 2012 Eight-Week - Second Summer Session view Lexington Farmers Market @ UK view Wed	31 SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view SPUR meeting view American Red Cross Lifeguarding Course #10 view Thu

May 21

Academic Calendar: Midterm of 2012 Four-Week Intersession

Reset Page

UKNOW University of Kentucky News

Most Popular Articles

Most Recent Articles

Campus Calendar

Mon, 05/21/2012

Repeats every day until Fri May 25 2012 .
Mon, 05/21/2012

Tue, 05/22/2012

Repeats every day until Fri May 25 2012 .
Tue, 05/22/2012

Wed, 05/23/2012

Navigation

More

In the news

UK doctor believes the cure for Alzheimer's is closer than ever before

Kids' hospitals, med schools join to fight abuse

Markey receives $6.25 million to study deadly cancer

WUKY seeks volunteers to help answer calls, take pledges for Summer Fund Drive

Related Articles

Mon, 05/21/2012

Repeats every day until Fri May 25 2012 .Mon, 05/21/2012

Tue, 05/22/2012

Repeats every day until Fri May 25 2012 .Tue, 05/22/2012

Wed, 05/23/2012

Navigation

More

In the news

Repeats every day until Fri May 25 2012 .
Mon, 05/21/2012

Repeats every day until Fri May 25 2012 .
Tue, 05/22/2012