Allison Elliott-Shannon

By

College: Medicine

Sanders-Brown Center on Aging Contributes to Fight Against Alzheimer's

Published: Apr 26, 2013

 

 

 

LEXINGTON, Ky. (April 26, 2013) — Alzheimer's disease is on the rise, but the University of Kentucky Sanders-Brown Center on Aging is a major player in the fight against this debilitating condition. Since the founding of the SBCoA in 1979, and the federal funding of the SBCoA Alzheimer's Disease Center (ADC) in 1985, the center has made many contributions to the body of knowledge about Alzheimer's and related brain aging conditions.

 

The facts about Alzheimer's disease are staggering. An estimated 5.2 million Americans and approximately 34 million people worldwide have Alzheimer’s and other dementias.  Nearly half (45 percent) of people age 85-plus have Alzheimer’s disease. Because age is the greatest risk factor for dementia, these numbers are expected to escalate rapidly and potentially triple by the year 2050 as the baby boom generation ages. In the US alone, the 2013 cost of Alzheimer’s is projected to be $203 billion. 

 

While deaths from other major diseases such as cancer, heart disease, and HIV decreased significantly between 2000 and 2010, deaths from Alzheimer’s disease increased by 68 percent. Alzheimer’s is now the sixth leading cause of death in the U.S.

 

"It is imperative that we discover more about the underlying mechanisms that lead to Alzheimer’s and other neurodegenerative disorders, and develop effective interventions to reduce the risk, slow the progression, or prevent the onset of these devastating age-related diseases. The overall goal of the Sanders-Brown Center on Aging (SBCoA) is to generate and disseminate new knowledge about the aging process and age-related brain diseases through cutting-edge research, education and outreach, and clinical programs.  Research at SBCoA is at the forefront of the field," said SBCoA director Linda Van Eldik, who has been at the center since 2010.

 

Contributions by the Sanders-Brown Center on Aging fall into four broad categories: research on biomarkers; cellular and molecular level research; lifestyle research; and drug development.

 

Research on Biomarkers: Changes in the brain consistent with Alzheimer’s pathology can develop 10-20 years before memory impairment is evident. This emphasizes the importance of developing new methods to detect very early changes, or biomarkers, in living individuals in the absence of cognitive impairment. 

 

Researchers at SBCoA are exploring several approaches to the development of novel biomarkers, including the use of structural and functional neuroimaging procedures, the detection of novel biomarkers in cerebrospinal fluid (CSF) and blood, and the application of sophisticated computational models. These studies may help us identify individuals at risk for dementia, and therefore tailor future therapeutic interventions to the individuals who are most likely to benefit.

 

Cellular and Molecular Level Research: Work at SBCoA is defining how abnormal changes and dysregulated mechanisms in the brain can contribute to the progression of disease.  Some of these important cellular and molecular mechanisms include contributions from amyloid and tau pathology, abnormal aggregations of proteins, brain inflammation and oxidative stress, genetic variants, prior head injury, and vascular problems.  Understanding the earliest changes that occur in the brain may help us to develop more effective interventions by targeting these disease mechanisms.

 

Lifestyle Research: SBCoA research is defining the importance of lifestyle modifications in reducing the risk of dementia and maintaining a healthy brain as one ages.  Activities that are good for the heart also appear to be good for the brain, including regular exercise, eating a healthy diet, staying mentally and socially connected, and monitoring blood pressure, blood sugar, cholesterol and body weight.

 

Drug Development: Researchers at SBCoA are also working with the national Alzheimer’s consortium as well as private foundations and pharmaceutical companies to perform clinical trials of the latest drug candidates, to directly determine if our research volunteers will benefit from promising new therapeutic interventions.

 

"When the SBCoA began in the late 1970’s, very little was known about Alzheimer’s disease.  The field as a whole did not understand how the pathological changes in the brain occurred, nothing was known about genetic risk factors, there were no medications available, and we didn’t have good ways of even diagnosing the disease. The Center and the field in general have come a huge distance since then," Van Eldik said.

 

"There is real hope on the horizon in our fight against age-related brain disorders.  But we can’t stop now.  We need to continue to pursue our important work on understanding why and how some individuals transition from successful cognitive aging to development of cognitive impairment and eventual dementia.  We also need to more rapidly translate these discoveries into new information, programs and interventions that will benefit older adults and those who care for them."

 

MEDIA CONTACT: Allison Elliott, Allison.Elliott@uky.edu

 

 

 

sbca_seeknowledge.jpg
April
 
 
 
 
 
1
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Last day to withdraw from the University or reduce course load. Students can withdraw or reduce course load after this date only for “urgent non-academic reasons.”
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
R. C. May Photography: Paul Shambroom: Lost
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Last Day to Withdraw or Reduce Course Load
Fri
2
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Bill Adams: Blue Madness
R. C. May Photography: Paul Shambroom: Lost
Open House: Selections from the John and Sue Wieland Collection
Sat
3
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Bill Adams: Blue Madness
R. C. May Photography: Paul Shambroom: Lost
Open House: Selections from the John and Sue Wieland Collection
Book of Mormon Trip
Sun
4
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Undergraduate Research Information Session
Undergraduate Research Information Session
Edible Garden Workday
Stop and See The Sexperts
Graduate Student Congress Meeting (April)
Mon
5
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Tye Dye Tuesday
Use of Urban Forests to Improve Water Quality
Women of the World: Abby Wambach
Tue
6
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Stop and See The Sexperts
Free HIV Screenings
Ag Awareness Day: Horticulture Club Sale
Wed
7
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Last day for candidates for a May 2016 degree to schedule a final examination in the Graduate School
R. C. May Photography: Paul Shambroom: Lost
Horticulture Club Cabin Fever Sale
UK Elder Care Lunch & Learn - Letting Go of the Reins
Symposium of Food Systems Studies
Thu
8
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Deadline for applying for admission to the Graduate School for the 2016 Four-Week Summer Session
R. C. May Photography: Paul Shambroom: Lost
Horticulture Club Cabin Fever Sale
Holi
Fri
9
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Volunteering 101
House Party
Sat
10
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Sun
11
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Innovation Seminar: Sustainable Transportation
Mon
12
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Kick Butts Day
Periscope with a Bike Mechanic (morning)
Periscope with a Bike Mechanic (afternoon)
Tye Dye And Papa Johns with Fusion
Tue
13
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
4th Annual Bike to Campus Day & On-the-Spot Safety Checks
Stop and See The Sexperts
Fusion Blitz Week Service Day
Wed
14
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Undergraduate Research Information Session
Get Your DIY On! Fix-It Station Demonstrations
Fusion Game Night
Tour de Downtown Art
Thu
15
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
High Elevation Archaeological Research in the Northern Wind River Range, Wyoming
Fri
16
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Donut Tour on Two Wheels
PharmD Open House
PharmD Open House
UK Spring Family Reunion
Sat
17
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Sprint for Scholarships 5K
Sun
18
Monday through Wednesday - Students are prohibited from changing academic major
One + One
Undergraduate Research Information Session
Stop and See The Sexperts
Mon
19
Monday through Wednesday - Students are prohibited from changing academic major
One + One
R. C. May Photography: Paul Shambroom: Lost
Creason Lecture
Tue
20
One + One
Monday through Wednesday - Students are prohibited from changing academic major
R. C. May Photography: Paul Shambroom: Lost
Ping Pong Ball Drop
Wed
21
One + One
Last day for candidates for a May 2016 degree to sit for a final examination
R. C. May Photography: Paul Shambroom: Lost
Wildcat Wrap-Up
Go 'Inside the Hit Factory' With Author, New Yorker Writer John Seabrook
Soup & Substance / Trending Topics
UK RSA Block Party
Thu
22
One + One
R. C. May Photography: Paul Shambroom: Lost
Fri
23
One + One
R. C. May Photography: Paul Shambroom: Lost
UK Dance Ensemble Spring Concert
Sat
24
One + One
R. C. May Photography: Paul Shambroom: Lost
UK Dance Ensemble Spring Concert
Sun
25
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
Mon
26
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
Four-Week Intersession registration and add/drop continue for students enrolled in the 2016 Spring Semester
R. C. May Photography: Paul Shambroom: Lost
Building a Rain Garden
Tue
27
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
R. C. May Photography: Paul Shambroom: Lost
Showcase of Undergraduate Scholars
Wed
28
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
R. C. May Photography: Paul Shambroom: Lost
Paws for Stress Relief
Some Intersections of Art and Science - A Public Lecture by Nobel Laureate Frank Wilczek
Thu
29
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
R. C. May Photography: Paul Shambroom: Lost
Last Day of Classes
Fri
30
One + One
Final Grading window is open. The final deadline for submission of grades online in the grading portal is midnight, May 9.
R. C. May Photography: Paul Shambroom: Lost
Oral Cancer Awareness 5K
ARBOR DAY at The Arboretum
Sat

Repeats every day on March, April, May every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun May 22 2016 .
Fri, 04/29/2016

Fri, 04/29/2016

Repeats every day on March, April, May every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun May 22 2016 .
Sat, 04/30/2016

Sat, 04/30/2016

Reset Page