Allison Elliott-Shannon

By

College: Medicine

Study: Transfusion Not Always Best Treatment for Anemia, Age of Stored Blood May Play a Role

Published: Oct 11, 2011

 

LEXINGTON, Ky. (Oct. 11, 2011) — University of Kentucky researchers, including lead author Samy Selim of the Division of Cardiovascular Medicine and the Saha Cardiovascular Research Center, have recently published a paper suggesting that transfusion may not always be the best treatment for hospitalized patients with anemia. Results suggest the age of stored blood may be a factor in negative effects of transfusion.

 

The paper, "Plasma levels of sphingosine l-phosphate are strongly correlated with haemotocrit, but variably restored by red blood cell transfusions," appeared in a recent edition of the journal Clinical Science.

 

For many years, the traditional treatment for hospitalized patients in the United States who have developed anemia — whether associated with medical illness, surgical procedures or trauma — has been red blood cell transfusion, despite the absence of supporting data in many patient populations.

 

While still a life-saving measure in emergency situations such as acute bleeding, emerging evidence suggests that transfusions may, in fact, be associated with risk beyond commonly-held concerns of microbial transmission and acute reactions. Researchers are currently trying to understand the mechanism behind this observed deleterious effect of transfusion, which seems to correlate with the duration of storage of blood (blood for transfusion may currently be stored up to 42 days).

 

Red blood cells carry and deliver an important biologically active lipid mediator, sphingosine 1-phosphate (S1P), which is required for maintaining the integrity of blood vessels. 

 

In the study, investigators confirmed that individuals with anemia have lower circulating levels of  S1P. They found that transfusion to correct anemia does not always restore levels of S1P and the inability to restore S1P may be associated with the age of the transfused blood.  Levels of S1P decrease during storage of red blood cells, which may explain why transfusion of older blood is less able to restore S1P levels.  

 

These findings could help to explain some of the reasons that  blood transfusions can have adverse consequences. Future efforts may focus on supplementing red blood cells with S1P in an attempt to improve outcomes in transfusion.

 

Study authors include lead author Samy Selim; Susan Smyth, chief of the Division of Cardiovascular Medicine and a core member of the Saha CVRC research faculty; Manjula Sunkara, Abdlghaffar K. Salous, Steve W. Leung, Alison Bailey, Andrew J. Morris, and Charles L. Campbell, all of the UK Division of Cardiovascular Medicine; Richard Charnigos of the UK College of Public Health; and Evgeny V. Berdyshev of the University of Illinois at Chicago.  

bloodinbags.jpg
November
 
 
 
 
 
 
1
Free Saturday Swing Dance Lessons
College of Pharmacy Open House
Iron Pour
UK Women's Choir 20th Anniversary Concert
Adventure Hiking & Rappelling @ Red River Gorge
Pickin' Time Mountain Music and Harvest Day
Purposeful Retirement: Planning Your Next Stage of Life
Diwali Dhoom 2014
Sat
2
UK Percussion Ensemble
Day Hike
Curator Tour: Take My Word For It
Sun
3
Industry Career Week: Resumes and Cover Letters
Kentucky Volleyball vs. Morehead State
Mon
4
Industry Career Week: How to Impress Your Boss in 90 Days
Rock Star Professionalism Series
UK Lab Band
Tue
5
Industry Career Week: Networking and Job Search
Social Enterprise and Innovation / Certified Nonprofit Professional Program Informational Meeting
Circle of Love Name Distribution
Appalachian Forum with Dr. Fran Ansley
Dana Harper Gallery Reception
Wed
6
Career Assessment Workshop
LNFS Presents: Zona Sur
LNFS Presents: The Grand Budapest Hotel
UK Jazz Ensemble
Circle of Love Name Distribution
Abstract Workshop
Lauren Potter
Thu
7
LNFS Presents: V for Vendetta
Last Day to Withdraw or Reduce Course Load
Circle of Love Name Distribution
R.C. May Photography Lecture Series: Marvin Heiferman
Men's Soccer vs. Charlotte
Kentucky Volleyball vs. Georgia
Free Friday Evening Swing Dance
Fri
8
Kentucky Football vs. Georgia
Free Saturday Swing Dance Lessons
The Power of Poetry
The Lexington Lowdown and Free Lindy Hop Workshop
Swing Dance Featuring Live music by"The Metrognomes Orchestra"
Sat
9
UK Combos Concert
Kentucky Volleyball vs. Missouri
Sun
10
Circle of Love Name Distribution
Mon
11
UK Sax Ensembles
Job Club - Interviewing Strategies
Undergraduate Research Information Session
Jose Abisambra Presentation on Current Alzheimer's Research
Women of the World: Judy Smith
Tue
12
Internship Info Session
LNFS Presents: Reservoir Dogs
Refugee Life in America
#UKEDTALKS: International Opportunities for Education Majors
Leadership Assessment
Wed
13
Career Assessment Workshop
LNFS Presents: Iron Man 3
Chili and Pie Cook-Off Supper
#TrendingTopics: Vegetarians vs. Meat-Eaters
Campus Polar Plunge to benefit Special Olympics KY
LNFS Presents: La Demora
Thu
14
LNFS Presents: Pretty in Pink
LNFS Presents: Mean Girls
Fri
15
Free Saturday Swing Dance Lessons
Sat
16
Kentucky Volleyball vs. Florida
Greek Cinematography: Critical Approach and Discussion
"Storied Streets" Documentary Showing about Experiences of Homelessness
Sun
17
The Vexillology (the study of maps) Contest
UK Rep Bands Concert
College of Agriculture, Food & Environment 2014 Celebration of Land-Grant Research
Amanda Rogers, "Black Flags, ISIS 'Swag' & Jihadi Rap: Marketing Militancy after the Arab Spring"
Stories of Homelessness: Panel Discussion
Mon
18
The Vexillology (the study of maps) Contest
A Positive Approach to Caregiving Conference
Education Abroad Open House
CatWatch Party
Appalachian Forum and Film Screening of "Up the Ridge"
Tue
19
The Vexillology (the study of maps) Contest
LNFS Presents: The Princess and the Frog
Pinterest Party
International Games Day
Global Design with Phil Duncan
Caregiver Support Group
OXFAM Social Issues Banquet
Wed
20
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: I Travel Because I Have To, I Come Back Because I Love You
LNFS Presents: The Big Lebowski
International Education Week Keynote Speaker: Christie Vilsack, Senior Advisor for International Education at USAID
Tobacco-free Tailgate 5 Year Anniversary
Bollywood Night
Thu
21
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: Water For Elephants
4th Annual Markesbery Symposium on Aging & Dementia
Freedom from Fear: On Black Childhood and Other Dangers
Bouldering @ Stone Fort
MEAT.
Fri
22
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
Free Saturday Swing Dance Lessons
Sat
23
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
UK Symphony Band and UK Concert Band
Sun
24
The Vexillology (the study of maps) Contest
Free Thanksgiving Shuttle to Blue Grass Airport
Mon
25
Free Thanksgiving Shuttle to Blue Grass Airport
Job Club - What is your money habitude?
Multicultural Student Thanksgiving Dinner
Tue
26
Thanksgiving - Academic Holidays
Free Thanksgiving Shuttle to Blue Grass Airport
Wed
27
Thanksgiving - Academic Holidays
Thu
28
Thanksgiving - Academic Holidays
Fri
29
Thanksgiving - Academic Holidays
Free Saturday Swing Dance Lessons
Kentucky Volleyball vs. Arkansas
Sat
30
 
Sun
 
 
 
 
 
 

Wed, 11/26/2014 - Sat, 11/29/2014

Wed, 11/26/2014

Reset Page