Laura Dawahare

Three Researchers from the Sanders-Brown Center on Aging Awarded Bright Focus Grants

Published: Jul 14, 2014

LEXINGTON, Ky. (July 14, 2014) — The Bright Focus Foundation has announced that three different researchers from the Sanders-Brown Center on Aging at the University of Kentucky have received Bright Focus grants for 2014.

 

Professor Steve Estus and associate professors Harry LeVine and Paul Murphy were each recognized for their work on Alzheimer's disease.

 

"Only 25 Bright Focus grants are awarded worldwide each year, so it's an achievement to get one. But three Bright Focus grants in a single year is truly exceptional," said Dr. Michael Karpf, UK HealthCare's executive vice president of health affairs. "These awards are an appropriate reflection of Sanders-Brown's international reputation for groundbreaking research into the causes and treatments for Alzheimer's and other cerebrovascular disease."

 

The Bright Focus programs are designed to provide initial funding for highly innovative experimental ideas. Most awardees use the grant funds to demonstrate key findings that lead to later interest and additional funding from industrial or governmental funding agencies. This year, Bright Focus awarded 25 grants worth a total of $8.7 million. The three grants awarded to the Sanders-Brown Center on Aging total $605,000.

 

Each of the three grants awarded to Sanders-Brown addresses a different aspect of Alzheimer's disease (AD) detection, prevention and treatment.

 

Building on previous research identifying hereditary differences in a gene known to be associated with a reduced risk of AD, Dr. Estus and his lab will try to demonstrate that this gene inhibits the production of cells beneficial to the prevention of AD.  Ultimately, this work could lead to new treatments for the prevention of AD.

 

LeVine's lab will be looking into a molecule that helps in early detection of AD. By honing in on the specific neurons in the AD brain marked by this molecule, Dr. LeVine and his team hope to learn what makes humans uniquely susceptible to AD, with long term goals to improve animal models of AD and identify potential therapeutic strategies.

 

In 2012, Murphy worked with fellow Sanders-Brown researcher Dana Niedowicz to create a genetically engineered mouse with obesity, diabetes and AD-like symptoms to study why obese people seem to have a higher risk for AD or other dementias.  This mouse with "mixed dementia" will be used to search for treatments among therapies that have already undergone clinical safety trials or are already being used to treat other conditions.

 

Dr. Guy Eakin, vice president of scientific affairs for the Bright Focus Foundation, notes that three Bright Focus awards for Sanders-Brown researchers isn't a complete surprise.

"Sanders-Brown has long been a well-recognized leader in Alzheimer’s disease research," Eakin said. "Their work is exceptionally compelling, and ranks amongst the most promising ideas currently being studied in the effort to understand and conquer Alzheimer’s disease."

 

Bright Focus Foundation is a nonprofit organization supporting research and providing public education to help eradicate brain and eye diseases, including Alzheimer's disease, macular degeneration, and glaucoma.  Bright Focus awards are intended to advance early-stage, investigator-initiated research around the world by providing funding for unique research hypotheses with the potential to grow into future clinical realities. For more information on the Bright Focus Foundation and its 2014 grants, go to www.brightfocus.org/Grants2014

 

The University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) was established in 1979 and is one of the original ten National Institutes of Health (NIH)-funded Alzheimer’s disease Research Centers. SBCoA is internationally acclaimed for its progress in the fight against illnesses facing the aging population. 

 

 

sbcoa_estus_lab.jpgsbcoa_levine_lab.jpgsbcoa_murphy_lab.jpg
November
 
 
 
 
 
 
1
Free Saturday Swing Dance Lessons
College of Pharmacy Open House
Iron Pour
UK Women's Choir 20th Anniversary Concert
Adventure Hiking & Rappelling @ Red River Gorge
Pickin' Time Mountain Music and Harvest Day
Purposeful Retirement: Planning Your Next Stage of Life
Diwali Dhoom 2014
Sat
2
UK Percussion Ensemble
Day Hike
Curator Tour: Take My Word For It
Sun
3
Industry Career Week: Resumes and Cover Letters
Kentucky Volleyball vs. Morehead State
Mon
4
Industry Career Week: How to Impress Your Boss in 90 Days
Rock Star Professionalism Series
UK Lab Band
Tue
5
Industry Career Week: Networking and Job Search
Social Enterprise and Innovation / Certified Nonprofit Professional Program Informational Meeting
Circle of Love Name Distribution
Appalachian Forum with Dr. Fran Ansley
Dana Harper Gallery Reception
Wed
6
Career Assessment Workshop
LNFS Presents: Zona Sur
LNFS Presents: The Grand Budapest Hotel
UK Jazz Ensemble
Circle of Love Name Distribution
Abstract Workshop
Lauren Potter
Thu
7
LNFS Presents: V for Vendetta
Last Day to Withdraw or Reduce Course Load
Circle of Love Name Distribution
R.C. May Photography Lecture Series: Marvin Heiferman
Men's Soccer vs. Charlotte
Kentucky Volleyball vs. Georgia
Free Friday Evening Swing Dance
Fri
8
Kentucky Football vs. Georgia
Free Saturday Swing Dance Lessons
The Power of Poetry
The Lexington Lowdown and Free Lindy Hop Workshop
Swing Dance Featuring Live music by"The Metrognomes Orchestra"
Sat
9
UK Combos Concert
Kentucky Volleyball vs. Missouri
Sun
10
Circle of Love Name Distribution
Mon
11
UK Sax Ensembles
Job Club - Interviewing Strategies
Undergraduate Research Information Session
Jose Abisambra Presentation on Current Alzheimer's Research
Women of the World: Judy Smith
Tue
12
Internship Info Session
LNFS Presents: Reservoir Dogs
Refugee Life in America
#UKEDTALKS: International Opportunities for Education Majors
Leadership Assessment
Wed
13
Career Assessment Workshop
LNFS Presents: Iron Man 3
Chili and Pie Cook-Off Supper
#TrendingTopics: Vegetarians vs. Meat-Eaters
Campus Polar Plunge to benefit Special Olympics KY
LNFS Presents: La Demora
Thu
14
LNFS Presents: Pretty in Pink
LNFS Presents: Mean Girls
Fri
15
Free Saturday Swing Dance Lessons
Sat
16
Kentucky Volleyball vs. Florida
Greek Cinematography: Critical Approach and Discussion
"Storied Streets" Documentary Showing about Experiences of Homelessness
Sun
17
The Vexillology (the study of maps) Contest
UK Rep Bands Concert
College of Agriculture, Food & Environment 2014 Celebration of Land-Grant Research
Amanda Rogers, "Black Flags, ISIS 'Swag' & Jihadi Rap: Marketing Militancy after the Arab Spring"
Stories of Homelessness: Panel Discussion
Mon
18
The Vexillology (the study of maps) Contest
A Positive Approach to Caregiving Conference
Education Abroad Open House
CatWatch Party
Appalachian Forum and Film Screening of "Up the Ridge"
Tue
19
The Vexillology (the study of maps) Contest
LNFS Presents: The Princess and the Frog
Pinterest Party
International Games Day
Global Design with Phil Duncan
Caregiver Support Group
OXFAM Social Issues Banquet
Wed
20
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: I Travel Because I Have To, I Come Back Because I Love You
LNFS Presents: The Big Lebowski
International Education Week Keynote Speaker: Christie Vilsack, Senior Advisor for International Education at USAID
Tobacco-free Tailgate 5 Year Anniversary
Bollywood Night
Thu
21
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: Water For Elephants
4th Annual Markesbery Symposium on Aging & Dementia
Freedom from Fear: On Black Childhood and Other Dangers
Bouldering @ Stone Fort
MEAT.
Fri
22
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
Free Saturday Swing Dance Lessons
Sat
23
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
UK Symphony Band and UK Concert Band
Sun
24
The Vexillology (the study of maps) Contest
Free Thanksgiving Shuttle to Blue Grass Airport
Mon
25
Free Thanksgiving Shuttle to Blue Grass Airport
Job Club - What is your money habitude?
Multicultural Student Thanksgiving Dinner
Tue
26
Thanksgiving - Academic Holidays
Free Thanksgiving Shuttle to Blue Grass Airport
Wed
27
Thanksgiving - Academic Holidays
Thu
28
Thanksgiving - Academic Holidays
Fri
29
Thanksgiving - Academic Holidays
Free Saturday Swing Dance Lessons
Kentucky Volleyball vs. Arkansas
Sat
30
 
Sun
 
 
 
 
 
 

Repeats every week until Sat Nov 29 2014 except Sat Sep 20 2014, Sat Oct 18 2014.
Sat, 11/29/2014

Sat, 11/29/2014

Mon, 12/01/2014

Tue, 12/02/2014

Reset Page