Carl Nathe

By

College: Agriculture, Food and Environment

UK Researcher Awarded Grant for Equine Viral Arteritis Research

Published: Mar 6, 2013

LEXINGTON, Ky. (March 6, 2013) — Udeni Balasuriya, a professor at the University of Kentucky Maxwell H. Gluck Equine Research Center, recently received $2.9 million to identify the genetic factors responsible for establishment of the equine arteritis virus (EAV) carrier state in stallions. The five-year grant was awarded by the U.S. Department of Agriculture-Agriculture and Food Research Initiative.

 

According to Nancy Cox, associate dean for research in UK’s College of Agriculture and administrative leader for UK’s Ag Equine Programs, Balasuriya’s grant was ranked the highest in its category, unusual for a USDA grant program that normally targets food animals.

This is one of the largest grants awarded in the College of Agriculture in the last year, she said, and is a special kind that includes funds for getting results out to the public in the fastest, most efficient way.

 

Outbreaks of equine viral arteritis (EVA) result in significant economic losses to the equine industry due to high rates of foal loss in pregnant mares, death in young foals and establishment of the carrier state in stallions. The virus is maintained in the equine population between breeding seasons by persisting in carrier stallions.

 

The project stems from research by a graduate student, Yun Young Go, who worked in Balasuriya’s laboratory at the Gluck Center. The initial focus of her project involved the characterization of the EAV target cell population(s) in equine white blood cells. White blood cells are important because they eliminate cells attacked by the virus.

 

According to Balasuriya, the study demonstrated that EAV could infect isolated cultured white blood cells in the lab.

 

“Subsequently, this study was expanded to include the latest information available from the equine genome,” he said.

 

The genome studies were done in collaboration with Ernie Bailey and James N. MacLeod, both researchers at the Gluck Center.

 

Co-principal investigators of the study include seven Gluck Center faculty members—Sergey Artiushin, Bailey, Frank Cook, David Horohov, MacLeod, Edward Squires, Peter Timoney and Mats Troedsson. This collaboration includes expertise in the areas of immunogenetics, genomics, molecular virology and viral pathogenesis, equine reproduction, equine immunology, diagnostic pathology, molecular and cell biology and equine infectious diseases.

The study will further investigate the possibility that susceptibility may be different in different horses. The nature of the susceptibility will be studied first in more isolated cells in the laboratory, then later with stallions.

 

“This cutting edge research under the leadership of Dr. Balasuriya will use new approaches to identify genetic factors associated with the establishment of persistent EAV in stallions,” said Mats Troedsson, director of the Gluck Equine Research Center and chair of the Department of Veterinary Science at UK. “The recent sequencing of the equine genome by an international consortium, including several scientists from the Gluck Equine Research Center, has made this kind of research possible. Exploring genetic variations among horses to explain mechanisms on how they respond to viral infections is an exciting research area that is expected to not only improve our understanding of viral diseases in general, but also provide veterinarians and horse owners with new diagnostics and tools for individual management and treatments in the future.”

 

The study will provide research opportunities for graduate and undergraduate students to address EAV through integrating functional genomic studies and education. Findings from the studies will be disseminated through seminars and symposiums.

 

The mission of the Gluck Center is scientific discovery, education and dissemination of knowledge for the benefit of the health and well-being of horses. The Gluck Center faculty conducts equine research in six targeted areas: genetics and genomics, infectious diseases and immunology, musculoskeletal science, parasitology, pharmacology/toxicology and reproductive health.

 

For more information on the Gluck Center, visit http://www.ca.uky.edu/gluck.

 

 

 

MEDIA CONTACT: Jenny Evans, (859) 218-1089

horses_running.jpg
June
 
 
 
1
 
Wed
2
 
Thu
3
Postdoctoral Research Symposium (Hosted by Society of Postdoctoral Scholars)
Fri
4
 
Sat
5
 
Sun
6
LINKS Center Summer Workshop on Social Network Analysis
Mon
7
LINKS Center Summer Workshop on Social Network Analysis
End of the Summer I 2016 Four-Week Intersession
Tue
8
LINKS Center Summer Workshop on Social Network Analysis
Wed
9
LINKS Center Summer Workshop on Social Network Analysis
UK Writing Center Open for Summer Session 2 (June 9-August 4)
First Day of Classes of the Summer II 2016 Eight-Week Session
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
10
UK Writing Center Open for Summer Session 2 (June 9-August 4)
LINKS Center Summer Workshop on Social Network Analysis
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
11
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Family Day Workshop
Sat
12
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
13
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
14
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
15
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
16
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
17
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Film Screening: Artists on the Body
Fri
18
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
19
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
20
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
21
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
22
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
23
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Steve Zahn: One Night Only
Thu
24
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
25
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
26
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
27
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
28
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
29
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
30
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
 
 

Repeats every day until Fri Jul 01 2016 .
Sun, 06/26/2016

Repeats every day until Sun Jul 31 2016 .
Sun, 06/26/2016

Repeats every day until Fri Jul 01 2016 .
Mon, 06/27/2016

Reset Page