Allison Elliott-Shannon

By

College: Medicine

UK Researchers: Parkinson's Disease Risk Greater in Those Exposed to Trichloroethylene

Published: Nov 30, 2011

 

LEXINGTON, Ky. (Nov. 30, 2011) — A University of Kentucky faculty member is a contributing author on a new study demonstrating a connection between a common solvent chemical and Parkinson's disease. Dr. Franca Cambi of the UK Kentucky Neuroscience Institute collaborated with researchers from across the U.S. on a paper recently published in the Annals of Neurology.

The novel study looked at a cohort of human twins wherein one twin had been occupationally exposed to trichloroethylene (TCE) and other chemicals believed to be linked to development of Parkinson's.

 

TCE has been previously linked to Parkinson's disease through prior research by UK authors and others, including the 2008 paper, "Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity," and the 2010 paper, "Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats." The 2008 paper was based upon a study of factory workers in a facility using chemicals that have been linked to development of Parkinson's disease.

 

In the most recent paper, the authors demonstrated that in addition to TCE, increase in Parkinson's disease risk is also associated with exposure to percholorethylene (PERC) and carbon tetrachloride (CCI4).
 

Occupational or environmental exposure to TCE, PERC and CCI4 is common due to the extensive use of the chemicals in dry-cleaning solutions, adhesives, paints, and carpet cleaners. Despite the Food and Drug Administration (FDA) banning the use of TCE as a general anesthetic, skin disinfectant, and coffee decaffeinating agent in 1977, it is still widely used today as a degreasing agent. In the U.S., millions of pounds of TCE are still released into the environment each year and it is the most common organic contaminant found in ground water, detected in up to 30 percent of drinking water supplies in the country. 

 

The current epidemiological study, led by Drs. Samuel Goldman and Caroline Tanner of The Parkinson’s Institute in Sunnyvale, Ca., investigated exposure to TCE, PERC and CCI4 as they related to risk of developing Parkinson's disease. The team interviewed 99 twin pairs from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort in which one twin had Parkinson's and one didn’t, inquiring about lifetime occupations and hobbies. Lifetime exposures to six specific solvents previously linked to Parkinson's in medical literature — n-hexane, xylene, toluene, CCl4, TCE and PERC — were inferred for each job or hobby typically involving exposure to the chemicals.

 

While prior research has indicated a link between TCE exposure and Parkinson's disease, the current findings are the first to report a statistically significant association — a more than six-fold increased risk.  Researchers also found that exposure to PERC and CCI4 tended toward significant risk of developing the disease. 

 

This study focused on occupational exposures, but the solvents under investigation are pervasive in the environment. Lead author Goldman concluded: “Our findings, as well as prior case reports, suggest a lag time of up to 40 years between TCE exposure and onset of Parkinson's, providing a critical window of opportunity to potentially slow the disease process before clinical symptoms appear.”

 

The National Institute of Neurological Disorders and Stroke (NINDS) estimates that as many as 500,000 Americans have Parkinson's disease and more than 50,000 new cases are diagnosed annually.  While there is much debate regarding the causes of Parkinson's disease, studies suggest that genetic and environmental factors likely trigger the disease - which is characterized by symptoms such as limb tremors, slowed movement, muscle stiffness, and speech impairment.  Several studies have reported that exposure to solvents may increase risk of Parkinson's, but research assessing specific agents is limited.

 

 

MEDIA CONTACT: Allison Elliott, allison.elliott@uky.edu

annalsofneuro.jpg
February
1
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Sun
2
Undergraduate Research Information Session
Wildcat Wellness: Expressions (Creative Stress Relief)
Mon
3
National Student Exchange (NSE) Info Session
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Tanya Habjouqa: Recent Photographs
Lexington Tattoo Project
Wildcat Wellness: Relaxation
Tue
4
LNFS Presents: Groundhog Day
Wildcat Wellness: Meditation
Massage on the Go #1
Last Day to Drop a Course Without Appearing on Transcript
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Internship Info Session
Edward Ayers, "The Incomplete War" - 2015 Bale Boone Symposium
Wed
5
LNFS Presents: Interstellar
LNFS Presents: Ai Weiwei: Never Sorry
Tanya Habjouqa: Recent Photographs
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Edward Troye: Theme & Variation
Thu
6
LNFS Presents: Songcatcher
LNFS Presents: Wall-E
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Fri
7
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
8
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Family Program: Everyone Collects!
Sun
9
Blitz Week for STAT and TEAM WILDCAT
Wildcat Wellness: Expressions (Creative Stress Relief)
Mon
10
Blitz Week for STAT and TEAM WILDCAT
Employer Showcase: Day 1 Technical Career Fair
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: Successful Telephone Interview/Screening Tips and How to Choose & Prep your Professional References
Live Painting Performance
Coleman Hutchison, "Variations on the Word 'Dixie': Civil War Cultural Memory and a Song of the South" - 2015 Bale Boone Symposium
Love Letters for Seniors
Tue
11
Blitz Week for STAT and TEAM WILDCAT
Live Painting Performance
LNFS Presents: Caddyshack
Wildcat Wellness: Meditation
Employer Showcase: Day 2 Non-Technical Career Fair
Last Day to Drop a Course with 50% Refund
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Darwin Lecture Series
Wildcat Wednesday
#TrendingTopics: Space Exploration
Wed
12
Blitz Week for STAT and TEAM WILDCAT
Live Painting Performance
LNFS Presents: Taxi Driver
LNFS Presents: Gone Girl
National Student Exchange (NSE) Info Session
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
UK Elder Care Lunch & Learn - Legal Planning
Wildcat Wellness: Healthy Habits
"Fix Society" Leelah's Law
David Blight, "When Did the American Civil War End?" - 2015 Bale Boone Symposium
Thu
13
Blitz Week for STAT and TEAM WILDCAT
Live Painting Performance
LNFS Presents: The Great Gatsby
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Candlelight Vigil for Chapel Hill Victims
Placing Modern Moonshine in America: Exploring Appalachia’s Role
ASA Photography Project
Fri
14
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Artist Talk
Sat
15
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
CIFA X CSSA Chinese Basketball Tournament
Film Screening: 2 States
Sun
16
Wildcat Wellness: Expressions (Creative Stress Relief)
Omicron Delta Kappa Leadership Awards, Reception, & Mixer
Mon
17
LNFS Presents: Dear White People
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Party Gras
CatWatch Party #2
Tue
18
Caregiver Support Group
LNFS Presents: Wreck-It Ralph
Wildcat Wellness: Meditation
National Student Exchange (NSE) Info Session
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Wed
19
LNFS Presents: Nightcrawler
LNFS Presents: Ip Man
Celebration at UK vs Texas A & M Women’s Basketball Game, Memorial Coliseum
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Depression Screening Day
Celebration at UK vs Texas A & M Women’s Basketball Game
Thu
20
LNFS Presents: The Bang Bang Club
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Curator Tour
Fri
21
Free Saturday Swing Dance Lessons
Celebration at UK vs Auburn Men’s Basketball Game
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Cross Cultural Workshop
Cross Cultural Workshop
Life After UK Conference
Spring Comedian: Jim Gaffigan
Sat
22
Cross Cultural Workshop
Cross Cultural Workshop
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
23
Graduate & Professional School Prep
Convocation
Wildcat Wellness: Expressions (Creative Stress Relief)
Graduate School & Professional School Prep
Behind the Lens: Beau Willimon
Mon
24
National Student Exchange (NSE) Info Session
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: Interview Strategies from the Other Side of the Table
Graduate School & Professional School Prep: Getting into Medical School
Cuba-U.S. Relations: a panel discussion
Pinterest Party #2
CRE and CCO Speaker: Laura Simms
Tue
25
LNFS Presents: Inception
Wildcat Wellness: Meditation
Fellows Founders Week Luncheon
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Graduate & Professional School Prep: Explaining Graduate School Tests
Graduate & Professional School Prep: Write a Winning Personal Statement
Wed
26
LNFS Presents: The Birds
LNFS Presents: The Hunger Games: Mockingjay Pt. 1
Guest Lecture: President Emeritus Mark Yudof of the University of California – Berkley
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Astronaut Dr Story Musgrave
Graduate & Professional School Prep: Graduate School 101
80's Night
African Dance Night
African Dance Night
Thu
27
LNFS Presents: Superbad
LNFS Presents: Little Shop of Horrors
Cultural Coffee Hour
The Blue Tie Bash
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Robert C. May Photography Endowment Lecture: Tanya Habjouqa
Fri
28
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Stay Warm with Swing Dancing
Sat
Feb 27
LNFS Presents: Superbad 02/27/2015

Repeats every week until Sat Apr 25 2015 .
Sat, 02/28/2015

Repeats every day until Sun Apr 12 2015 except Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Sat, 02/28/2015

Repeats every day on January, February, March, April every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Apr 12 2015 except Mon Jan 12 2015, Mon Jan 26 2015, Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Sat, 02/28/2015

Repeats every day until Sun Apr 12 2015 except Mon Jan 26 2015, Mon Feb 02 2015, Mon Feb 09 2015, Mon Feb 16 2015, Mon Feb 23 2015, Mon Mar 02 2015, Mon Mar 09 2015, Mon Mar 16 2015, Mon Mar 23 2015, Mon Mar 30 2015, Mon Apr 06 2015.
Sat, 02/28/2015

Reset Page