Laura Dawahare

By

College: Medicine

UK Sanders-Brown Center on Aging Selected for Major Clinical Trial of Drug to Prevent Alzheimer's Disease

Published: Jun 19, 2014

 

LEXINGTON, Ky. (June 19, 2014) -- The University of Kentucky's Sanders-Brown Center on Aging is participating in a landmark multi-center clinical trial of an experimental drug that has the potential to prevent Alzheimer's disease (AD).

 

The A4 Study will recruit 1,000 participants ages 65-85 to test an amyloid antibody that may prevent memory loss caused by Alzheimer's disease. Amyloid is a protein normally produced in the brain that can build up in older people, forming plaque deposits in the brain. Scientists believe this buildup of deposits may play a key role in the eventual development of Alzheimer's.

 

Sanders-Brown is the only center in Kentucky and the only center within 200 miles of Lexington participating in the study.

 

Dr. Gregory Jicha of the Sanders-Brown Center on Aging is enthusiastic about the impact this study might have for the 35 million people suffering from Alzheimer's disease worldwide.

 

"As the baby boomer generation ages, the incidence of Alzheimer's and other age-related dementias will grow exponentially," Jicha said. "As of today, there is no cure for Alzheimer's disease, so any opportunity to slow the progression of symptoms by intervening early in the disease process is important."

 

Since previous studies have demonstrated that changes in the brain occur many years before a person shows the signs of Alzheimer's disease-related dementia, researchers have targeted the amyloid plaques that accumulate in the aging brain as a means of identifying people at risk for developing AD and intervening before the onset of the earliest signs of memory loss.

 

A4 participant candidates will undergo a series of tests to determine their eligibility, including an imaging test called a PET scan to determine whether they do in fact have evidence of amyloid plaque buildup. This in itself is an interesting conundrum, said Jicha.

 

"Amyloid plaques don't guarantee that a person will develop Alzheimer's, but there seems to be a strong link between the two," said Jicha. "So using PET imaging to determine the buildup of amyloid plaques is similar to being tested for the BRCA1 gene for breast cancer: they help us determine who is at a higher risk for developing the disease in question."

 

Therefore, explains Jicha, patients who are identified by PET scan as at risk for Alzheimer's disease but aren't yet experiencing memory problems will now be able to explore their options for prevention and/or treatment.

 

Jicha notes that the A4 study is just one of many Alzheimer's-related clinical trials being conducted at the Sanders-Brown Center on Aging.

 

"We have clinical trials that target the entire continuum for Alzheimer's disease, from prevention to treatment,"  Jicha said. "But we'll never be able to answer the crucial question: 'Does this work?' If we can't enroll enough people for the research."

See video

 

The University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) http://www.uky.edu/coa/ was established in 1979 and is one of the original ten National Institutes of Health (NIH)-funded Alzheimer’s disease Research Centers. The SBCoA is internationally acclaimed for its progress in the fight against illnesses facing the aging population.

 

For more information about the importance of volunteering for clinical trials, go to https://www.youtube.com/watch?v=4TDfOG8blwU&list=PL0vC9-Q8LFcx88jdTlLemFkxCPXRk-pzB

 

For more information on participation in the clinical trials underway at the Sanders-Brown Center on Aging, contact Sarah Tarrant at 859-323-1331.

 

jicha_gregory-2.jpg
October
 
 
 
1
Internship Info Session
LNFS Presents: Dallas Buyers Club
College of Law Welcomes Trevor Potter
Wed
2
Dancing at Lughnasa
LNFS Presents: Notes on Marie Menken
LNFS Presents: Edge of Tomorrow
UK Jazz Ensemble/ UK Lab Band
Earth & Environmental Science Student Open House
"Nerd Night" Exhibit and Concert
"Anne Braden: Southern Patriot" Film Screening and Discussion
Thu
3
Dancing at Lughnasa
LNFS Presents: My Neighbor Totoro
LNFS Presents: (500) Days of Summer
Men's Soccer vs. Old Dominion
Kentucky Volleyball vs. Alabama
Fri
4
Dancing at Lughnasa
Kentucky Football vs. South Carolina
Free Saturday Swing Dance Lessons
Rock Climbing @ Red River Gorge
Cross Cultural Workshop 2014
Swing Dancing!
Sat
5
Dancing at Lughnasa
Cross Cultural Workshop 2014
UK Children's Hospital/Birthing Center Annual Perinatal Loss "Walk To Remember"
Kentucky Volleyball vs. Texas A&M
Sun
6
Dancing at Lughnasa
Murals of Baltimore
Resumes and Cover Letters
Mon
7
Dancing at Lughnasa
Murals of Baltimore
Networking and Job Search
UK Choristers
Rock Star Professionalism Series
Stillness in Motion: The Essence of Symmetry - presented by Dr. Carl Lee, Mathematics
Tue
8
Dancing at Lughnasa
Murals of Baltimore
LNFS Presents: Night of the Living Dead
UK Law Day
Wed
9
Dancing at Lughnasa
Murals of Baltimore
LNFS Presents: Dawn of the Planet of the Apes
Mark Berry, Guest Percussion Recital
National Depression Screening Day
LNFS Presents: Torch Song Trilogy
Thu
10
Dancing at Lughnasa
LNFS Presents: Shut Up and Play the Hits
LNFS Presents: Watchmen
KLJ Data Privacy Symposium
Family Weekend Check-in
Big Blue Pantry Food Drive #1
Kentucky Women's Soccer vs. South Carolina
Family Weekend: Derek Hughes
Fri
11
Dancing at Lughnasa
Kentucky Football vs. ULM
Free Saturday Swing Dance Lessons
UK International Tent/ Tailgate Party
CT Surgery Symposium: Advances in the Surgical Management of Cardiothoracic Diseases:
Family Weekend Tent Party
Sat
12
Dancing at Lughnasa
DNT 101: A Taste of the Kentucky Doughnut Trail
Big Blue Pantry Food Drive #2
Kentucky Volleyball vs. Auburn
Sunday Lunch at Historic Spindletop Hall
Men's Soccer vs. Marshall
Sun
13
 
Mon
14
Job Club - Social Media and Your Career
Massage on the Go
Tue
15
LNFS Presents: The Last Samurai
UK Symphony Band Concert
Women's Forum Conference 2014
#TrendingTopics: Pornography vs. Morality
Wed
16
Career Assessment Workshop
LNFS Presents: The Tree of Life
LNFS Presents: Guardians of the Galaxy
UK Wind Symphony
Thu
17
LNFS Presents: Princess Mononoke
LNFS Presents: The Hitchhiker's Guide to the Galaxy
Kentucky Women's Soccer vs. Ole Miss
Berlin Philharmonic Wind Quintet
Fri
18
Paint the Town Blue
Free Kaplan Entrance Practice Exams
4th Annual Big Blue Soccer Tournament
Men's Soccer vs. New Mexico
Swing Dancing and Costumes?
Sat
19
Paint the Town Blue
UK Men's Chorus and acoUstiKats
Jazz Spectacular
UK Student Pajama Party
Kentucky Volleyball vs. LSU
Kentucky Women's Soccer vs. Florida
Sun
20
Paint the Town Blue
Midterm of 2014 Fall Semester
Returning to Work and Breastfeeding
Open Access Week Kickoff Event (Webcast)
Grad School 101
Royalty Showcase
Mon
21
Graduate and Professional School Prep Week: Preparing for Law School
Graduate and Professional School Prep Week: Grad School Panel: Surviving Your 1st Year
Film & Panel Discussion: Be Like Others
Graduate and Professional School Showcase
Your Publication, Your Choice: Choosing the Right Open Access Journal
Graduate and Professional School Prep Week
Graduate and Professional School Prep Week
Kitty Karnival
Tue
22
Study Tips for Medical School
LNFS Presents: Eternal Sunshine of the Spotless Mind
Thank-A-Donor Day
Campus Sustainability Day
Electronic Thesis and Dissertation Information Session
Getting Into Medical School
Wed
23
Writing a Winning Personal Statement
Career Assessment Workshop
LNFS Presents: Marimbas From Hell
LNFS Presents: The Fault in Our Stars
Generation Open: Researchers' Roles in the Age of Openness
Homecoming Street Fair
Thu
24
LNFS Presents: Kiki's Delivery Service
LNFS Presents: The Secret Life of Walter Mitty
"see blue." Day at Keeneland
Peanut Butter Drive
Pumpkin Carving Tournament
Fri
25
Kentucky Football vs. Mississippi State
Free Saturday Swing Dance Lessons
Sat
26
UK Women's Choir and Paws and Listen
Bill Cooper Faculty Recital
Sun
27
UK Trumpet Ensemble
Undergraduate Research Information Session "How to Find A Mentor"
Kentucky Men's Basketball Blue/White Scrimmage
Mon
28
Job Club - How To Get A Job at UK: Updates on IES Applicant Tracking System
Common Reading Experience Author Lecture: Presenting Ishmael Beah
Screening of the documentary Teached
Tue
29
Internship Info Session
LNFS Presents: The Shining
Pinterest Party
Leadership Assessment
"see boo." Halloween Party
Society for the Promotion of Undergraduate Research (SPUR) Meeting
#UKEDTALKS: Design Thinking with Dr. John Nash
Kentucky Volleyball vs. Tennessee
Wed
30
Career Assessment Workshop
LNFS Presents: Lucy
Film Viewing and Discussion of The Other Boleyn Girl
LNFS Presents: Papirosen
Kentucky Women's Soccer vs. Alabama
Thu
31
LNFS Presents: ParaNorman
LNFS Presents: Carrie
All Hallow's Eve Concert (UK Symphony Orchestra)
Work-Life Retirement Conference
Fri
 

Fri, 10/24/2014

Repeats every week until Sat Nov 29 2014 except Sat Sep 20 2014, Sat Oct 18 2014.
Sat, 10/25/2014

Sun, 10/26/2014

Reset Page