Laura Dawahare

By

College: Medicine

UK Sanders-Brown Center on Aging Selected for Major Clinical Trial of Drug to Prevent Alzheimer's Disease

Published: Jun 19, 2014

 

LEXINGTON, Ky. (June 19, 2014) -- The University of Kentucky's Sanders-Brown Center on Aging is participating in a landmark multi-center clinical trial of an experimental drug that has the potential to prevent Alzheimer's disease (AD).

 

The A4 Study will recruit 1,000 participants ages 65-85 to test an amyloid antibody that may prevent memory loss caused by Alzheimer's disease. Amyloid is a protein normally produced in the brain that can build up in older people, forming plaque deposits in the brain. Scientists believe this buildup of deposits may play a key role in the eventual development of Alzheimer's.

 

Sanders-Brown is the only center in Kentucky and the only center within 200 miles of Lexington participating in the study.

 

Dr. Gregory Jicha of the Sanders-Brown Center on Aging is enthusiastic about the impact this study might have for the 35 million people suffering from Alzheimer's disease worldwide.

 

"As the baby boomer generation ages, the incidence of Alzheimer's and other age-related dementias will grow exponentially," Jicha said. "As of today, there is no cure for Alzheimer's disease, so any opportunity to slow the progression of symptoms by intervening early in the disease process is important."

 

Since previous studies have demonstrated that changes in the brain occur many years before a person shows the signs of Alzheimer's disease-related dementia, researchers have targeted the amyloid plaques that accumulate in the aging brain as a means of identifying people at risk for developing AD and intervening before the onset of the earliest signs of memory loss.

 

A4 participant candidates will undergo a series of tests to determine their eligibility, including an imaging test called a PET scan to determine whether they do in fact have evidence of amyloid plaque buildup. This in itself is an interesting conundrum, said Jicha.

 

"Amyloid plaques don't guarantee that a person will develop Alzheimer's, but there seems to be a strong link between the two," said Jicha. "So using PET imaging to determine the buildup of amyloid plaques is similar to being tested for the BRCA1 gene for breast cancer: they help us determine who is at a higher risk for developing the disease in question."

 

Therefore, explains Jicha, patients who are identified by PET scan as at risk for Alzheimer's disease but aren't yet experiencing memory problems will now be able to explore their options for prevention and/or treatment.

 

Jicha notes that the A4 study is just one of many Alzheimer's-related clinical trials being conducted at the Sanders-Brown Center on Aging.

 

"We have clinical trials that target the entire continuum for Alzheimer's disease, from prevention to treatment,"  Jicha said. "But we'll never be able to answer the crucial question: 'Does this work?' If we can't enroll enough people for the research."

See video

 

The University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) http://www.uky.edu/coa/ was established in 1979 and is one of the original ten National Institutes of Health (NIH)-funded Alzheimer’s disease Research Centers. The SBCoA is internationally acclaimed for its progress in the fight against illnesses facing the aging population.

 

For more information about the importance of volunteering for clinical trials, go to https://www.youtube.com/watch?v=4TDfOG8blwU&list=PL0vC9-Q8LFcx88jdTlLemFkxCPXRk-pzB

 

For more information on participation in the clinical trials underway at the Sanders-Brown Center on Aging, contact Sarah Tarrant at 859-323-1331.

 

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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
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Vivian Maier: On the Street
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Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
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Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
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Healthy Smoothie Demonstration
Healthy Smoothie Demonstration
Healthy Smoothie Demonstration
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Wed
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Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
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Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Thu
29
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Fri
30
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Family Say at the Art Museum
Sat
31
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Sun
 
 
 
 
 
 

Repeats every 0 months on the fourth Wednesday until Tue Jun 30 2015 .
Wed, 05/27/2015

Repeats every day on May, June, July every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Jul 26 2015 .
Wed, 05/27/2015

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