Allison Perry

UK Study Shows Potential New Way to Detect Colorectal and Other Cancers

Published: Apr 25, 2013

LEXINGTON, Ky. (April 25, 2013) — A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.

 

The study, published in Cell, discovers that an abnormal histone protein modification impairs a DNA repair machinery that controls cancer development, yielding a potential new way of detecting these types of colorectal cancers. It represents the first time that epigenetic histone marks regulate the genome maintenance system.

 

DNA errors created during DNA replication can lead to many forms of cancer, including colorectal cancer. Cells possess DNA mismatch repair (MMR) machinery that aids in correcting these errors, thus preventing disease development. Defects in MMR genes lead to development of colorectal cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon referred to as microsatellite instability (MSI). Some cancers develop in individuals who possess MSI without MMR gene defects, and until now, the reason for this has been unknown.

 

Dr. Li’s study shows that defects in SETD2 – an enzyme that is not involved in MMR but chemically or epigenetically modifies histone proteins associated with DNA that control the regulation of gene expression and DNA replication – prevent the association of MMR proteins with damaged DNA, thus preventing DNA mismatch repair.

 

"This study provides new clues to cancer etiology, that is, from the classical genetic defects to abnormal epigenetic modifications in the future," Li said. "Since SETD2 mutations have been shown in many types of cancers, including clear cell renal cell carcinoma, lung cancer, gastric cancer and hematological malignancies, our next goal is to determine association of MMR defects with these cancers, as well as SETD2 mutations in MSI-positive MMR-competent colorectal cancers."

 

Although most colorectal cancers are preventable or treatable with proper screening, colorectal cancer remains the second-leading cause of cancer death in the United States. Kentucky is ranked in the highest tiers for both colorectal and lung cancer incidence and death.

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu 

li_guo-min2012.jpg
February
 
1
Graduate Student Congress Meeting (February)
Mon
2
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Tue
3
K Crew Recruitment
Last Day to Drop a Course Without Appearing on Transcript
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Wed
4
K Crew Recruitment
Bill Adams: Blue Madness
Undergraduate Research Information Session
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
5
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Off-Campus Student Services' Wildcat Apartment Hop #1
Panel Discussion: Historic Homes
Fri
6
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
7
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
8
K Crew Recruitment
Sex and Chocolate
Law School Prep Workshop
Mon
9
K Crew Recruitment
Healthy Relationships Workshop
How to Package Communication and Technical Skills on your Resume
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
2016 Distinguished Industry Lecture Series
Tue
10
K Crew Recruitment
Last Day to Receive 50% Refund
Pinterest Party #1
Off-Campus Student Association Information Session
Get Yourself Tested!
Showcase your Talents: Building a Strong Portfolio
An Evening with Tatyana Ali and Amir Windom: Progression Towards Success
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
How to Survive a Plague
Wed
11
K Crew Recruitment
Coffee & Canvases
Off-Campus Student Association Information Session
Study Abroad in Berlin!
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
12
K Crew Recruitment
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Ash and the Market: Ceramic Exchange, Political Economy, and the Late to Terminal Classic Transformation of the Kiuic Polity
Fri
13
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Learn to Play Bridge
Workshop: The Artist Statement
Sat
14
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
15
K Crew Recruitment
See ICT
Patterson School Guest Speaker Series
Mon
16
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
See ICT
UK Women's Forum February Board Meeting
Tue
17
K Crew Recruitment
Food For Thought
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Wed
18
Undergraduate Research Information Session
Soup & Substance: Real Talk, Real Issues, & Real People Series
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
19
PharmD Interviews
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Off-Campus Student Services' Wildcat Apartment Hop #2
SAB Underground Formal
Fri
20
PharmD Interviews
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
21
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
22
Undergraduate Research Information Session
University Health Service- Let It Go
Mon
23
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
University Health Service- Know Your Numbers
University Health Service- Mindful Eating
Tue
24
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK Elder Care Lunch & Learn - Don't Blame It On Aging
Ravi Zacharias at Memorial Coliseum
Wed
25
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
26
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Dimensions of Political Ecology Conference
Eday Talk by Georgetown Toyota President Wil James
Do What You Are: Connecting Personalities w/ Profession
Off- Campus Student Services' Wildcat Apartment Hop #3
Traditions and Transformations in Tz’utujil Territory, Lake Atitlan, Guatemala, 500 BC – 1524 AD
Concert in the Museum: Central Music Academy
Fri
27
Dimensions of Political Ecology Conference
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK E-Day
Sat
28
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
DanceBlue Rave Hour
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Sun
29
Monday through Friday - Midterm Grading window is open. The mid-term grading window will close at midnight on March 11.
Monday through Wednesday - Students are prohibited from changing academic major
Bodies Of Evidence: Provocations: A Transnational Feminist History Project
Mon
 
 
 
 
 
Feb 09
Healthy Relationships Workshop 02/09/2016

Tue, 02/09/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Apr 03 2016 .
Wed, 02/10/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Mon Apr 04 2016 .
Wed, 02/10/2016

Reset Page