Allison Perry

By

College: Medicine

UK Study Shows Promise for New Nerve Repair Technique

Published: Aug 8, 2014

LEXINGTON, Ky. (Aug. 8, 2014) ­– A multicenter study including University of Kentucky researchers found that a new nerve repair technique yields better results and fewer side effects than other existing techniques.

 

Traumatic nerve injuries are common, and when nerves are severed, they do not heal on their own and must be repaired surgically. Injuries that are not clean-cut – such as saw injuries, farm equipment injuries, and gunshot wounds – may result in a gap in the nerve.

 

To fill these gaps, surgeons have traditionally used two methods: a nerve autograft (bridging the gap with a patient's own nerve taken from elsewhere in the body), which leads to a nerve deficit at the donor site; or nerve conduits (synthetic tubes), which can cause foreign body reactions or infections.

 

The prospective, randomized study, conducted by UK Medical Director of Hand Surgery Service Dr. Brian Rinker and others, compared the nerve conduit to a newer technique called a nerve allograft. The nerve allograft uses human nerves harvested from cadavers. The nerves are processed to remove all cellular material, preserving their architecture while preventing disease transmission or allergic reactions.

 

Participants with nerve injuries were randomized into either conduit or allograft repair groups. Following the surgeries, independent blind observers performed standardized assessments at set time points to determine the degree of sensory or motor recovery.

 

The results of the study suggested that nerve allografts had more consistent results and produced better outcomes than nerve conduits, while avoiding the donor site morbidity of a nerve autograft.

 

Rinker, a principal investigator of the study, describes it as a "game-changer."

 

"Nerve grafting has remained relatively unchanged for nearly 100 years, and both of the existing nerve repair options had serious drawbacks," Rinker said. "Our study showed that the new technique processed nerve allograft ­– provides a better, more predictable and safer nerve gap repair compared to the previous techniques."

 

Rinker also noted that work is underway to engineer nerve allografts with growth factors which would guide and promote nerve regeneration, theoretically leading to even faster recoveries and better results.

 

Other medical centers participating in the trial included the Indiana Hand to Shoulder Center in Indianapolis, Georgia Hand, Shoulder and Elbow in Atlanta, and the Curtis National Hand Center in Baltimore.

 

The study was funded by Axogen, Inc. Results were presented at the Annual Combined Meeting of the American Association for Hand Surgery, American Society of Reconstructive Microsurgery, and the American Society of the Peripheral Nerve. Rinker's paper was voted Outstanding Paper of the Joint Session. 

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

brian_rinker.jpg
January
 
 
 
 
1
 
Thu
2
 
Fri
3
 
Sat
4
 
Sun
5
 
Mon
6
 
Tue
7
 
Wed
8
 
Thu
9
 
Fri
10
 
Sat
11
 
Sun
12
 
Mon
13
Job Club: Job Search Strategies for the New Year: A 15 Day Action Plan
Tue
14
Bicycle Trivia
LNFS Presents: Hercules
Wildcat Wellness: Meditation
Wed
15
LNFS Presents: Dazed and Confused
LNFS Presents: Boyhood
MLK "I Have A Dream" Silent March, Vigil & Program
Thu
16
MLK Multicutural Org Fair
Fri
17
 
Sat
18
 
Sun
19
 
Mon
20
 
Tue
21
LNFS Presents: Mission Impossible 3
Wildcat Wellness: Meditation
Caregiver Support Group
Wed
22
LNFS Presents: Big Hero 6
LNFS Presents: Together With You (He ni zai yi ki)
Thu
23
LNFS Presents: Five Broken Cameras
LNFS Presents: Scott Pilgrim vs. the World
National Student Exchange (NSE) Info Session
Cultural Coffee Hour
Fri
24
Pershing Rifles Drill Meet
Welcome Back Students Swing Dance!
Sat
25
 
Sun
26
Career & Major Exploration Session @ 11 a.m.
Career & Major Exploration Session @ Noon
Career & Major Exploration Session @ 2 p.m.
Mon
27
Pinterest Party #1
Job Club: Using Networking to Find and Land a Hidden Job
Career & Major Exploration Session @ 1 p.m.
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Tue
28
LNFS Presents: There Will Be Blood
Wildcat Wellness: Meditation
National Student Exchange (NSE) Info Session
Chapel Talk: Why The Church Should Support Marriage Equality
Wed
29
LNFS Presents: Mulholland Drive
LNFS Presents: Fury
Tattoo Exhibit
CatWatch Party #1
Thu
30
LNFS Presents: Clerks
LNFS Presents: Friday
Cultural Coffee Hour
Faculty Media Depot Opening Reception
Fri
31
 
Sat
Reset Page