Allison Elliott-Shannon

By

College: Medicine

Van Eldik Awarded Alzheimer's Drug Discovery Research Grant

Published: Jan 24, 2011

LEXINGTON Ky. (Jan. 24, 2011) - Linda J. Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, has been awarded a $750,000 grant to further her research into a possible treatment for Alzheimer's disease. The grant is from the Edward N. And Della L. Thome Memorial Foundation, and was one of only eight Awards in Alzheimer's Disease Drug Discovery Research to be given in the U.S. in 2010.

Van Eldik's research project focuses on developing an orally active, small molecule drug to inhibit the protein kinase known as p38alphaMAPK. The protein stimulates overproduction of detrimental inflammatory molecules in the brain called proinflammatory cytokines. In normal brain activity, inflammatory and anti-inflammatory molecules operate together to keep brain functions in balance. In the brains of people who have Alzheimer's disease, this balance appears to be disrupted and the overproduction of proinflammatory cytokines leads to poor neuron function, and eventually symptoms of dementia.

Because inflammatory and anti-inflammatory molecules both serve important roles in normal brain function, it is not possible to treat Alzheimer's disease by turning off all inflammatory molecules in the brain. Rather, a successful compound must selectively target proteins like p38alphaMAPK that drive the disruptive inflammatory responses. Van Eldik's goal is to develop a selective small molecule drug to act on this culprit kinase to suppress overactive production of pro-inflammatory cytokines.

Successful so far in an animal model of Alzheimer's disease, Van Eldik's p38-targeted compounds have promise. The grant from the Thome Foundation will enable her to refine the best compound for possible use as a drug. Research will continue in cellular and animal models, as Van Eldik and her collaborators work to identify an optimal candidate drug for future clinical development and testing in humans.

Learn more about Van Eldik and the Sanders-Brown Center on Aging here.

vaneldik_photo22_dec09.jpegvaneldik_photo2_dec09.jpeg
July
 
 
1
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
2
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
3
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
4
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
5
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
6
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Artful Sunday: Benday Dot Day
Sun
7
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Mon
8
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
9
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
10
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
11
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
12
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
International Youth Water Justice Summit
Sat
13
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
14
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Mon
15
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
16
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers (with Dr. Greg Jicha)
Wed
17
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
18
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
19
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Color Water Balloon Fight
Sat
20
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Summer Salon: Landscape as Subject with Tom Barnes, Photographer
Sun
21
EPIC Ministry Weekly Gathering
Mon
22
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
23
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
24
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
25
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
26
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
27
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
28
 
Mon
29
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
30
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers (with Mary Crowley Schmidt)
Wed
31
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
 
 

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Thu, 07/31/2014

Fri, 08/01/2014 - Wed, 09/03/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Fri, 08/01/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Sat, 08/02/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Sun, 08/03/2014

Reset Page