Allison Elliott-Shannon

By

College: Medicine

Aging Study Seeks Adults with Down Syndrome

Published: Nov 18, 2010

LEXINGTON, Ky. (Nov. 18, 2010) – Life expectancy for individuals with Down syndrome has increased dramatically - from a life expectancy of only  25 years a generation ago, to greater than 60 years today. As individuals with Down syndrome live longer than ever before, they also confront more problems associated with aging - including Alzheimer's and dementia. Complications resulting from Down syndrome increase the risk of Alzheimer's, and can accelerate the onset of memory disorders. To better understand - and hopefully ameliorate - this set of circumstances, the University of Kentucky Sanders-Brown Center on Aging is seeking individuals with Down syndrome, age 35 and up, to participate in a research study designed to identify early markers of the development of Alzheimer's disease in individuals with Down syndrome.
 

The study is headed by Sanders-Brown researchers Elizabeth Head and Frederick Schmitt, and is funded by a five-year, $2.4 million grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development within the National Institutes of Health. Study organizers are seeking individuals with Down syndrome, either with or without symptoms of a memory disorder or dementia.
 

Participants will be tracked to follow any neurological, cognitive and memory changes, as well as to examine brain changes via magnetic resonance imaging (MRI) and regular measurement of biomarkers in blood. Each participant will be asked to come to the Sanders-Brown Center on Aging twice a year.
 

"We will have participants assessed on a six month basis using tests of language, learning and memory," said Head, associate professor, Department of Molecular and Biomedical Pharmacology, UK College of Medicine, and a researcher in Sanders-Brown." Each year, we will measure brain changes using magnetic resonance imaging (MRI) and specifically look for changes in white matter integrity – fibers that connect different parts of the brain. We will also use protein profiling methods to measure changes with age in the blood of our participants."
 

"This is an exciting opportunity to improve our knowledge about how and why persons with Down syndrome show pronounced changes in brain aging," said Schmitt, who also holds an appointment as professor, Department of Neurology, UK College of Medicine. "This study, along with others of its type, could provide important information in the development of treatments for, and prevention of, dementia in people with Down syndrome and could also lead to insights into treatments and prevention of Alzheimer’s disease in people without Down syndrome."
 

Volunteers who may be eligible include persons with Down syndrome, age 35 and older with or without signs of Alzheimer’s disease. Volunteers must be interested in participating in a five-year research study. In addition, the volunteer, a family member or caregiver will need to answer questions about their health. Participants and their guardians will not receive direct compensation from the study, however they may benefit from the medical examinations, cognitive testing, blood tests and brain scans provided during the course of the study. If any part of the study examinations reveals evidence of illness or disease, a study physician will notify the participant's guardian and primary care physician within 72 hours.
 

This longitudinal project is a team effort and includes UK and Sanders-Brown Center on Aging faculty: Dr. Gregory Jicha, Dr. Allison Caban-Holt, Dr. Brian Gold, Dr. David Powell, Dr. Richard Kryscio, Dr. William Robertson, Dr. Stephen Scheff, Dr. Peter Nelson, Dr. Harry LeVine and Dr. Christopher Norris. In addition, Dr. Tony Wyss-Coray at Stanford University School of Medicine and Dr. Ira Lott at University of California, Irvine, are collaborators. The study scientists also will get input from Dr. Jose DeLeon, UK Department of Psychiatry and Mental Health Research Center; Dr. Harold Kleinert, UK Human Development Institute; as well as members including Betsy Dunnigan, acting deputy commissioner of the Kentucky State Cabinet for Health and Family Services; Dr. Allan Brenzel, clinical director with Department of Behavioral Health, Development and Intellectual Disabilities in Frankfort; Traci Brewer, chairperson of the Down Syndrome Association of Central Kentucky; Diana Merzweiler, executive director of Down Syndrome of Louisville Inc.; and Janet Gora, executive director of the Down Syndrome Association of Greater Cincinnati.
 

 For more information or to volunteer for the research study, contact Roberta Davis at (859) 257-1412 extension 479 or rdavi3@uky.edu.

man_with_down_syndrome.jpg
March
1
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
2
Wildcat Wellness: Expressions (Creative Stress Relief)
Resume & Cover Letters that Work
Mon
3
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Grad Salute
2nd Annual UK Work-Life Summer Camps Fair
UK Elder Care Lunch & Learn - Keeping Your Brain Healthy
Successful Networking & Job Search
Guest Lecture
Documentary Screening: "Forgotten Wars, Forgotten Victims"
Bangladeshi Garment Worker Speak Out
A Reading by Nic Brown
CatWatch Party #3
Tue
4
LNFS Presents: The Mighty Ducks
Wildcat Wellness: Meditation
Internship Info Session
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Art Therapy Table
OUTspoken with J Mase III
Appalachian Forum with Crystal Wilkinson entitled: Birds of Opulence: Black Women, Madness, and Resilience in Appalachia
Wed
5
LNFS Presents: Typeface
LNFS Presents: Space Jam
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Food for Hope
Thu
6
LNFS Presents: A Girl Walks Home Alone at Night
LNFS Presents: Pokémon: The First Movie
Cultural Coffee Hour
Grad Salute
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Japan Today
Holi: The Indian Festival of Colors
Fri
7
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Karnival Around The World
Graduate & Professional School Prep:KAPLAN Free Practice Test for MCAT and LSAT
PharmD Open House
Sat
8
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
9
Midterm of 2015 Spring Semester
Wildcat Wellness: Expressions (Creative Stress Relief)
GUEST LECTURE
Appalachian Forum with Rebecca Klenk, Topic: Global Uttarakhand: Development, Neoliberalism and Social Justice in Himalayan India
Ballroom Thieves
Mon
10
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: Staying Positive During A Job Search
Massage on the Go #2
Tue
11
LNFS Presents: Only Lovers Left Alive
Wildcat Wellness: Meditation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Jin Shin Jyutsu Self-Help Class
Leadership Assessment
#TrendingTopics: Immunization
True Songs
Wed
12
LNFS Presents: Into the Woods
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
LNFS Presents: Waiting for 'Superman'
Thu
13
LNFS Presents: Vertigo
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
LNFS Presents: Trainspotting
Fri
14
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
15
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
16
Spring 2015 Spring Vacation
Mon
17
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Tue
18
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wed
19
Spring 2015 Spring Vacation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Thu
20
Spring 2015 Spring Vacation
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Plating Design Demonstration with Dan Wu
Fri
21
Spring 2015 Spring Vacation
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
22
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sun
23
Wildcat Wellness: Expressions (Creative Stress Relief)
"Thrive: The Kentucky Wine Tradition" Documentary Screening
Mon
24
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Job Club: A Snapshot of the Central Kentucky Labor Market
Career & Major Exploration Session @ 1 p.m.
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Kentucky Teacher's Network Career Fair
Tue
25
LNFS Presents: Rear Window
Wildcat Wellness: Meditation
Internship Info Session
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Brazilian Conversation Hour
Healthy Smoothie Demonstration
Virtual Dementia Tour
Career & Major Exploration Session @ 1 p.m.
Healthy Smoothie Demonstration
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Women of the World: Rosario Dawson
Wed
26
LNFS Presents: The Imitation Game
LNFS Presents: Blade Runner
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Wildcat Wellness: Healthy Habits
Student & Employer Mixer
Young Artists Exhibit Reception
Thu
27
LNFS Presents: Psycho
LNFS Presents: The Life Aquatic with Steve Zissou
Cultural Coffee Hour
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Fri
28
Free Saturday Swing Dance Lessons
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Sat
29
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Lion King Trip
Sun
30
Wildcat Wellness: Expressions (Creative Stress Relief)
Mon
31
Wildcat Wellness: Relaxation
Tanya Habjouqa: Recent Photographs
Edward Troye: Theme & Variation
Same Difference: Michelle Grabner, Simone Leigh & Russell Maltz
Lexington Tattoo Project
Tue
 
 
 
 
Mar 03
Wildcat Wellness: Relaxation 03/03/2015
Reset Page