Allison Perry

By

College: Arts and Sciences

Glazer Receives Grant to Study Light-Activated Cancer Drugs

Published: Jan 31, 2013

LEXINGTON, Ky. (Jan. 31, 2013) — University of Kentucky assistant professor of chemistry Edith "Phoebe" Glazer has received an American Cancer Society Research Scholar Grant for $715,000 over four years to continue her research into ruthenium-based cancer drugs. These compounds are less toxic to healthy cells than a similar and widely used inorganic drug.

 

Cisplatin is a common platinum-based cancer drug used in a variety of cancer treatments. But while cisplatin kills cancer cells, it also attacks healthy cells, causing debilitating side effects. Ruthenium is another transition metal and belongs to the same group of the periodic table as iron.

 

Previously, the Glazer group developed two new ruthenium complexes designed to kill cancer cells while preserving healthy cells. These complexes are inert in the dark, but when activated with light, they become up to 200 times as toxic, and up to three times as potent as cisplatin against tumor cells.

 

Funded by the American Cancer Society, the new grant will allow Glazer's team to develop improved ruthenium-based compounds and to study their effectiveness. Using the strategy of combining organic ligands as building blocks that assemble around the ruthenium center “core,” a large family of compounds with different structures and properties can be rapidly synthesized. This is in marked contrast to approaches using compounds discovered in nature, called natural products, as chemotherapeutics.

 

Many chemotherapeutics are natural products, but their synthesis is challenging and there are limited chemical modifications that can be made into the molecules. In the ruthenium compounds, the organic components can be easily changed to alter chemical properties and possibly even what types of cells the compounds will enter in the body. The different structures can also potentially prevent the development of drug resistance, as tumors that become resistant to one particular ruthenium drug structure could be vulnerable to another ruthenium compound with a different structure. 

 

The efficacy of the compounds will be tested in different human cancer cell lines and in animal models to determine what cancer types can be treated. The group will also determine the biochemical process by which the compounds kill cells in order to optimize the drugs. The long-term goal of the research is to develop a targeted chemotherapeutic approach with reduced side effects that can be applied to a variety of cancer types.

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

microscope_closeup_1.jpg
August
 
1
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Mon
2
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Tue
3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Wed
4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
End of the Summer II 2016 Eight-Week Session
Thu
5
 
Fri
6
 
Sat
7
 
Sun
8
 
Mon
9
 
Tue
10
 
Wed
11
 
Thu
12
 
Fri
13
Parent and Families Open House
Sat
14
 
Sun
15
 
Mon
16
UK Women's Forum Board Meeting
Tue
17
 
Wed
18
 
Thu
19
K Week Kick-off
Off-campus Freshmen Check-in
Parent and Families Reception
Fri
20
New Student Induction Ceremony
Big Blue U
Getting Around Campus and Beyond
Campus Ruckus
Sat
21
UK Lex-Mart
K Team Lunch
Late-night Target Run
Sun
22
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Dinner with your K Team
Mon
23
We Are UK
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Campus Tours for K Teams
Tue
24
First Day of School Photos
First day of classes of Fall 2016
Wed
25
Pedalpalooza
First Day of School Photos
Thu
26
OCSS Wildcat Block Watch
Fri
27
Louis Zoellar Bickett: Saving Myself
Red River Gorge Adventure Trip for Out-of-State Students
Music Workshop for Teachers and Students: Michael Chandler
Flight 5191 Tenth Anniversary Memorial Service
Sat
28
Louis Zoellar Bickett: Saving Myself
Sun
29
Louis Zoellar Bickett: Saving Myself
Mon
30
Louis Zoellar Bickett: Saving Myself
Last Day to Add a Class for Fall 2016
Last Day to Withdraw to Receive 80% Refund
Tue
31
Louis Zoellar Bickett: Saving Myself
Wed
 
 
 
Aug 25
Pedalpalooza 08/25/2016

Fri, 08/26/2016

Sat, 08/27/2016 - Sun, 11/27/2016

Reset Page