Allison Perry

By

College: Arts and Sciences

Glazer Receives Grant to Study Light-Activated Cancer Drugs

Published: Jan 31, 2013

LEXINGTON, Ky. (Jan. 31, 2013) — University of Kentucky assistant professor of chemistry Edith "Phoebe" Glazer has received an American Cancer Society Research Scholar Grant for $715,000 over four years to continue her research into ruthenium-based cancer drugs. These compounds are less toxic to healthy cells than a similar and widely used inorganic drug.

 

Cisplatin is a common platinum-based cancer drug used in a variety of cancer treatments. But while cisplatin kills cancer cells, it also attacks healthy cells, causing debilitating side effects. Ruthenium is another transition metal and belongs to the same group of the periodic table as iron.

 

Previously, the Glazer group developed two new ruthenium complexes designed to kill cancer cells while preserving healthy cells. These complexes are inert in the dark, but when activated with light, they become up to 200 times as toxic, and up to three times as potent as cisplatin against tumor cells.

 

Funded by the American Cancer Society, the new grant will allow Glazer's team to develop improved ruthenium-based compounds and to study their effectiveness. Using the strategy of combining organic ligands as building blocks that assemble around the ruthenium center “core,” a large family of compounds with different structures and properties can be rapidly synthesized. This is in marked contrast to approaches using compounds discovered in nature, called natural products, as chemotherapeutics.

 

Many chemotherapeutics are natural products, but their synthesis is challenging and there are limited chemical modifications that can be made into the molecules. In the ruthenium compounds, the organic components can be easily changed to alter chemical properties and possibly even what types of cells the compounds will enter in the body. The different structures can also potentially prevent the development of drug resistance, as tumors that become resistant to one particular ruthenium drug structure could be vulnerable to another ruthenium compound with a different structure. 

 

The efficacy of the compounds will be tested in different human cancer cell lines and in animal models to determine what cancer types can be treated. The group will also determine the biochemical process by which the compounds kill cells in order to optimize the drugs. The long-term goal of the research is to develop a targeted chemotherapeutic approach with reduced side effects that can be applied to a variety of cancer types.

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

microscope_closeup_1.jpg
July
 
 
 
1
Other Streets: Photographs from the Collection
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Wed
2
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Thu
3
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Fri
4
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Sat
5
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Sun
6
 
Mon
7
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Fulbright Drop-In Hours
Tue
8
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Fulbright Drop-In Hours
Wed
9
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Fulbright Drop-In Hours
Thu
10
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Fri
11
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Sat
12
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Family Day At The Art Museum
Sun
13
 
Mon
14
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Tue
15
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Wed
16
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Thu
17
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Lecture: On Furniture
Fri
18
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Sat
19
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Sun
20
 
Mon
21
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Tue
22
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Wed
23
Other Streets: Photographs from the Collection
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
MoveWell Grand Opening
Thu
24
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Fri
25
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Sat
26
Vivian Maier: On the Street
Chester Cornett: Beyond the Narrow Sky
Chester Cornett: Beyond the Narrow Sky
Vivian Maier: On the Street
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Other Streets: Photographs from the Collection
Sun
27
 
Mon
28
 
Tue
29
Educator Social
Wed
30
 
Thu
31
 
Fri
 
Jul 29
Educator Social 07/29/2015

Wed, 07/29/2015

Fri, 08/07/2015

Fri, 09/11/2015

Wed, 09/23/2015 - Thu, 09/24/2015

Reset Page