Allison Perry

Groundbreaking UK Study Shows Key Enzyme Missing from Aggressive Form of Breast Cancer

Published: Mar 25, 2013

See video

 

LEXINGTON, Ky. (March 25, 2013) – A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain — providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells.

 

Normally, all cells — including cancerous cells — use glucose to initiate the process of making Adenosine-5'-triphosphate (ATP) for fuel to carry out essential functions. This process, called glycolysis, leads to other processes that use oxygen to make higher quantities of ATP — but solid tumor cells, which have little access to oxygen, are forced to rely almost exclusively on aerobic glycolysis for survival.  

 

Zhou's study, published in Cancer Cell, showed that the powerful transcription factor complex Snail-G9a-Dnmt1 is over-expressed in triple-negative breast cancer, inhibiting the enzyme fructose 1,6-bisphosphate (FBP1). The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer. This metabolic switch empowers the triple-negative breast cancer cells to suck more glucose from the body, increasing macromolecule biosynthesis in tumor cells and maintaining ATP production despite a dearth of nutrients and an oxygen-free environment.

 

Triple-negative breast cancer is the most deadly subtype of breast cancer, and tends to occur in women at a younger age. This subtype of breast cancer has poor clinical outcomes due to the early metastasis of tumor cells, resistance to chemotherapy, and the lack of specific drugs that target it. Identifying this change in the cancer's metabolic process provides major insight into developing drugs to target the disease, Zhou says. 

 

"These findings present significant insights regarding the development and progression of triple-negative breast cancer," said Zhou, associate professor of molecular and cellular biochemistry at UK. "They indicate that targeting the metabolic alteration will lead to an effective approach for treating this deadly disease."

 

Zhou's research was aided by the team in the Free Radical Biology in Cancer Shared Resource Facility (FRBC) of the Markey Cancer Center, directed by Dr. Allan Butterfield. The FRBC used an instrument called the Seahorse XF-96 Flux Analyzer to test and confirm the predictions of Zhou's findings in triple-negative breast cancer.

 

"The significance of this study rests in proving that triple negative breast cancer cells utilize glycolysis for survival and growth," Butterfield said. “The FRBC will assist Dr. Zhou in furthering this exciting research, potentially helping to identify key proteins in triple negative breast cancer cells that are expressed or modified differently than in control cells. Such knowledge may lead to new insights to potential approaches to treat this aggressive cancer."

 

Previously, Zhou has studied the role of the Snail complex in the cellular program known as the epithelial-mesenchymal transition (EMT), which is responsible for metastasis.

 

The study was also a collaboration with scientists at the University of Louisville (Dr. Teresa Fan) and at the University of Texas MD Anderson Cancer Center (Drs. Mien-Chie Hung and Jun Yao). 

 

 

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu

img_0882.jpg
August
 
 
 
 
 
1
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
2
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
3
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Artful Sunday: Wrapped Art
Sun
4
Employee Educational Assistance Award
Mon
5
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
6
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
7
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
8
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
9
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
10
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
11
Employee Educational Assistance Award
Mon
12
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
UK Working Moms Connection
Tue
13
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Wed
14
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
15
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
16
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
17
Employee Educational Assistance Award
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
18
Employee Educational Assistance Award
Mon
19
Employee Educational Assistance Award
Tue
20
Employee Educational Assistance Award
Chronic Disease Self-Management Program
Wed
21
Employee Educational Assistance Award
Thu
22
Employee Educational Assistance Award
Midnight Dodgeball Tournament
CARES First Year Focus Parent Meetings
CARES First Year Focus Parent Meetings
Parent and Families Reception
Residence Hall Floor Meeting
Off-campus Freshmen Check-in
K Team Meeting: K Week Kick-off
Death By Chocolate
Fri
23
Employee Educational Assistance Award
A Parent's Guide to Life after August 23
Campus Safety Information Session
Donut Avoid The Study
Common Cents: Money Management for College Students Session 1
See Blue...See Community
Succeeding in A Large Lecture Classroom
Horses, Bluegrass, Basketball, and More: Welcome to Kentucky
Success at Any Age: College Tips for Adult Learners
Write Right: Tips for Writing Well in College
Common Cents: Money Management for College Students Session 2
How to Graduate in Four Years
Parental Involvement in Fraternity and Sorority Life
Parents Watch for Warning Signs: Suicide Prevention for College Students
Preparing to be a Pre-Professional
Presentation U!: Where YOU are the Ultimate Presentation
Religious Life at UK
Successful Off-Campus Living
The Transfer Student Cruise: Navigating your way through UK
UK Parking & Transportation 101
You Heard It Here First: Tips From A Faculty Member
New Student Induction Ceremony
Minority Student Welcome
Transfer Student Cookout
K Team Meeting: K Week Overview
Men's Soccer vs. Georgia State
Big Blue U
Campus Ruckus
Campus Ruckus
Sat
24
Employee Educational Assistance Award
LNFS Presents: Jackass 3
LNFS Presents: Godzilla
Pedalpalooza
K Team Meeting: Lunch and Campus Tour
Center for Community Outreach: Do Good, Start Here.
UK Lex-Mart
Alternative Service Breaks: See the World, Change the World
From the Real World to the Amazing Race, Don't Wipeout: Your Advisor, Advising, and You
Blackboard Basics
Student Government Association Information Session
EMPOWER: Women’s Leadership Retreat Interest Session
Student Center Spectacular
Student Center Spectacular
Sun
25
Employee Educational Assistance Award
UK FUSION
UK Parking & Transportation 101
University of Kentucky Association for Transfer Students Interest Session
Candy, Condoms, Coffee
Cleaner, Healthier, Cheaper, Faster: Why Bicycling is the Best Way to Get Around Campus (and how to do it safely)
Working on Campus
K Team Meeting: Dinner with your K Team
Meijer Mania
Mon
26
Employee Educational Assistance Award
Last Day to Drop a Course with 100% Refund
Chem at UK Cafe-N-OJ with the Student American Chemical Society
Coffee (or Coke), Cookies, & Communication!: Come see blue. at Presentation U!
Don't Blow Yourself Up: Surviving Chemistry
Fraternity Recruitment Info Session
OMG! Did I Just E-Mail That to My Professor???
Surviving Your First Year and Beyond: Strategies To Do Well in Your Classes
Sustainable UK: Exploring Environmental Programs in the College of Agriculture, Food, and Environment (CAFE)
A User Guide for Your Mathematics Class
Discover the UK Art Museum
K Team Meeting: Common Reading Experience Discussion
Common Reading Introduction for International Students
Transfer Student Meet and Greet
We Are UK
Rec 'N Roll 2014
Big Blue Bingo Night
Mic Check
Tue
27
Employee Educational Assistance Award
Fraternity Recruitment Info Session
LNFS Presents: Jurassic Park
First Day of Classes
Open House - Special Collections Research Center
King Cookout
Campus Outreach
Opening Act: The Amazing Spider-Man 2
Wed
28
Employee Educational Assistance Award
Internship Info Session
LNFS Presents: Her
LNFS Presents: Captain America: The Winter Soldier
Student Involvement Fair
OrgSync Info session
LGBTQ* Welcome Back
Dive Into Diversity!
CATalyst's Dive Into Diversity Session
Residence Hall Floor Meetings
Thu
29
Employee Educational Assistance Award
Sea of Blue
One Last Beach Bash: RSA Block Party
LNFS Presents: Team America: World Police
Pills and Pizza
K Week Event: Pills and Pizza
Kentucky Volleyball vs. Wichita State
Kentucky Women's Soccer vs. Francis Marion
Fri
30
Employee Educational Assistance Award
LNFS Presents: Neighbors
The Tailgate "Kick-Off"
Kentucky Volleyball vs. Butler
Kentucky Football vs. UT-Martin
Kentucky Volleyball vs. Virginia Tech
Sat
31
Employee Educational Assistance Award
Kentucky Women's Soccer vs. Ohio
Men's Soccer vs. Belmont
Sun
 
 
 
 
 
 
Aug 30
LNFS Presents: Neighbors 08/30/2014

Sat, 08/30/2014

Sun, 08/31/2014

Tue, 09/02/2014

Reset Page