Allison Perry

New UK Study Shows Insight into Breast Cancer Cell Migration

Published: Oct 29, 2013

LEXINGTON, Ky. (Oct. 25, 2013) — A new study by University of Kentucky Markey Cancer Center researchers Min Chen and Kathleen O’Connor shows that a specific protein may assist breast cancer cells in metastasizing.

 

Tumor cells escape a primary tumor by a process called invasion. This process of invasion requires cells to migrate or move through tissue. This process is controlled by the restructuring of the actin cytoskeleton.

 

Signal transduction through the Rho-ROCK pathway can regulate the reorganization of the actin cytoskeleton such that it can form membrane ruffles at the front of a cell, which is used to efficiently move the cell forward, and form strong tension fibers (often referred to as stress fibers) within the body of the cell.

 

Published in Oncogene, the study found that a metastasis-associated protein known as S100A4 or metastasin can switch Rho function from making stress fibers to creating membrane ruffles.

 

Stress fibers are associated with non-motile cells, while their absence when coupled with the presence of membrane ruffles at the leading edge of cells is associated with cell migration and tumor invasion.

 

"Finding that S100A4 changes how Rho functions is a huge breakthrough and helps us to understand better how these two proteins contribute to metastasis," said O'Connor, professor in the Department of Molecular and Cellular Biochemistry at UK. "My lab is continuing to figure out just how these two proteins interact to drive invasion and metastasis. We are using this information to design better therapies for cancer patients. Currently, we do not have drugs that combat tumor invasion or metastasis despite the fact that metastasis is the major cause of cancer patient deaths. It is our hope that soon we will determine how to use selective drugs to target these pathways and improve the lives of cancer patients."

 

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.

 

microscope.jpg
July
 
 
1
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
2
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
3
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
4
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
5
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
6
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Artful Sunday: Benday Dot Day
Sun
7
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Mon
8
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
9
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
10
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
11
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
12
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
International Youth Water Justice Summit
Sat
13
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
14
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Mon
15
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
16
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers (with Dr. Greg Jicha)
Wed
17
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
18
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
19
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Color Water Balloon Fight
Sat
20
EPIC Ministry Weekly Gathering
Landscape/Mindscape: Selections from the Wells Fargo Collection
Summer Salon: Landscape as Subject with Tom Barnes, Photographer
Sun
21
EPIC Ministry Weekly Gathering
Mon
22
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
23
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers
Wed
24
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
25
Landscape/Mindscape: Selections from the Wells Fargo Collection
Fri
26
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sat
27
Landscape/Mindscape: Selections from the Wells Fargo Collection
Sun
28
 
Mon
29
Landscape/Mindscape: Selections from the Wells Fargo Collection
Tue
30
Landscape/Mindscape: Selections from the Wells Fargo Collection
Get Moving - A Walking Group for Caregivers (with Mary Crowley Schmidt)
Wed
31
Landscape/Mindscape: Selections from the Wells Fargo Collection
Thu
 
 

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Tue, 07/29/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Wed, 07/30/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Thu, 07/31/2014

Repeats every day on May, June, July, August every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday and on the first Sunday until Sun Aug 17 2014 .
Fri, 08/01/2014

Reset Page