Allison Perry

New UK Study Shows Insight into Breast Cancer Cell Migration

Published: Oct 29, 2013

LEXINGTON, Ky. (Oct. 25, 2013) — A new study by University of Kentucky Markey Cancer Center researchers Min Chen and Kathleen O’Connor shows that a specific protein may assist breast cancer cells in metastasizing.

 

Tumor cells escape a primary tumor by a process called invasion. This process of invasion requires cells to migrate or move through tissue. This process is controlled by the restructuring of the actin cytoskeleton.

 

Signal transduction through the Rho-ROCK pathway can regulate the reorganization of the actin cytoskeleton such that it can form membrane ruffles at the front of a cell, which is used to efficiently move the cell forward, and form strong tension fibers (often referred to as stress fibers) within the body of the cell.

 

Published in Oncogene, the study found that a metastasis-associated protein known as S100A4 or metastasin can switch Rho function from making stress fibers to creating membrane ruffles.

 

Stress fibers are associated with non-motile cells, while their absence when coupled with the presence of membrane ruffles at the leading edge of cells is associated with cell migration and tumor invasion.

 

"Finding that S100A4 changes how Rho functions is a huge breakthrough and helps us to understand better how these two proteins contribute to metastasis," said O'Connor, professor in the Department of Molecular and Cellular Biochemistry at UK. "My lab is continuing to figure out just how these two proteins interact to drive invasion and metastasis. We are using this information to design better therapies for cancer patients. Currently, we do not have drugs that combat tumor invasion or metastasis despite the fact that metastasis is the major cause of cancer patient deaths. It is our hope that soon we will determine how to use selective drugs to target these pathways and improve the lives of cancer patients."

 

The ability of a cell to invade more efficiently leads to increased rates of metastasis. Up until this point, how the Rho-ROCK pathway could promote both functions was unknown.

 

microscope.jpg
January
 
 
 
 
1
 
Thu
2
 
Fri
3
 
Sat
4
 
Sun
5
 
Mon
6
 
Tue
7
 
Wed
8
 
Thu
9
 
Fri
10
 
Sat
11
 
Sun
12
 
Mon
13
Job Club: Job Search Strategies for the New Year: A 15 Day Action Plan
Tue
14
Bicycle Trivia
LNFS Presents: Hercules
Wildcat Wellness: Meditation
Wed
15
LNFS Presents: Dazed and Confused
LNFS Presents: Boyhood
MLK "I Have A Dream" Silent March, Vigil & Program
Thu
16
MLK Multicutural Org Fair
Fri
17
 
Sat
18
 
Sun
19
 
Mon
20
 
Tue
21
LNFS Presents: Mission Impossible 3
Wildcat Wellness: Meditation
Caregiver Support Group
Wed
22
LNFS Presents: Big Hero 6
LNFS Presents: Together With You (He ni zai yi ki)
Thu
23
LNFS Presents: Five Broken Cameras
LNFS Presents: Scott Pilgrim vs. the World
National Student Exchange (NSE) Info Session
Cultural Coffee Hour
Fri
24
Pershing Rifles Drill Meet
Welcome Back Students Swing Dance!
Sat
25
 
Sun
26
Career & Major Exploration Session @ 11 a.m.
Career & Major Exploration Session @ Noon
Career & Major Exploration Session @ 2 p.m.
Mon
27
Pinterest Party #1
Job Club: Using Networking to Find and Land a Hidden Job
Career & Major Exploration Session @ 1 p.m.
Career & Major Exploration Session @ 2 p.m.
Career & Major Exploration Session @ 3 p.m.
Tue
28
LNFS Presents: There Will Be Blood
Wildcat Wellness: Meditation
National Student Exchange (NSE) Info Session
Chapel Talk: Why The Church Should Support Marriage Equality
Wed
29
LNFS Presents: Mulholland Drive
LNFS Presents: Fury
Tattoo Exhibit
CatWatch Party #1
Thu
30
LNFS Presents: Clerks
LNFS Presents: Friday
Cultural Coffee Hour
Faculty Media Depot Opening Reception
Fri
31
 
Sat
Jan 30
LNFS Presents: Clerks 01/30/2015

Mon, 02/02/2015

Tue, 02/03/2015

Repeats every week until Thu Apr 30 2015 except Wed Mar 18 2015.
Wed, 02/04/2015

Reset Page