Allison Elliott-Shannon

Research Represents Major Breakthrough in Macular Degeneration

Published: Apr 26, 2012

 

LEXINGTON, Ky. (April 26 , 2012) — University of Kentucky researchers, led by Dr. Jayakrishna Ambati, have made a major breakthrough in the “dry” form of age-related macular degeneration known as geographic atrophy (GA). GA is an untreatable condition that causes blindness in millions of individuals due to death of retinal pigmented epithelial cells. The paper, "DICER1 loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88," was published in the April 26 online edition of the premier journal Cell.

 

Ambati, professor of physiology, and professor and vice chair of ophthalmology and visual sciences at UK, is a leader in the field of macular degeneration research. Previous research from the Ambati laboratory published in the journal Nature showed that in human eyes with geographic atrophy there is a deficiency of the enzyme DICER1, leading to accumulation of toxic Alu RNA molecules in the retinal pigmented epithelium. The Cell paper shows that when these RNAs build up in the eye they trigger activation of an immune complex known as the NLRP3 inflammasome. In turn, this leads to the production of a molecule known as IL-18, which causes death of retinal pigmented epithelial cells and vision loss by activating a critical protein known as MyD88.

 

Importantly, Ambati and colleagues found evidence that activity of the inflammasome, IL-18, and MyD88 were all increased in human eyes with GA. They then showed that blocking any of these components could prevent retinal degeneration in multiple disease models. The researchers are excited that blocking these pathways could herald a new potential therapy for GA, for which there is no approved treatment.

 

Ambati is working with iVeena Pharmaceuticals, Inc. of Salt Lake City to commercialize therapies for geographic atrophy. iVeena can be contacted at info@i-veena.com.

 

Authors on the paper include Ambati as well as Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdonaovich, Romulo J.C. Albuquerque, Judi Z. Baffi and Mark E. Kleinman, all of the UK Department of Opthalmology and Visual Science. Additional authors include: William W. Hauswirth and Vince A. Chiodo of the University of Florida; Jennifer F. Kugel, James A. Goodrich and Steven L. Ponicsan of the University of Colorado; Gautaum Chaudhuri of Meharry Medical College; Michael P. Murphy of the MRC Mitochondrial biology Unit; Joshua L. Dunaief of the University of Pennsylvania; Balamurali K. Ambati of the University of Utah and the Veterans Affairs Salt Lake City Healthcare System; Yuichiro Ogura of the Nagoya City University Graduate School of Medical Sciences, Japan; Jae Wook Yoo and Dong-ki Lee of Sungkyunkwan University, Korea; Patrick Provost of Université Laval, Quebec; David R. Hinton of the University of Southern California; and Gabriel Nunez of the University of Michigan Medical School.

 

Ambati is also the Dr. E. Vernon and Eloise C. Smith Endowed Chair in Macular Degeneration Research.

 

This research was supported by the National Eye Institute, the Doris Duke Charitable Foundation, the Burroughs Wellcome Fund, and Research to Prevent Blindness.

 

 

MEDIA CONTACT: Allison Elliott, allison.elliott@uky.edu

 

 

hazel-eyes.jpg
April
 
 
1
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Baseball vs. Louisville
Kentucky Children's Garden Spring Break Special!
Pinterest Party #2
Tue
2
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents Ferris Bueller's Day Off
Men's Tennis vs. Illinois
UK Softball vs. Louisville
UK Men's Tennis vs. Northern Kentucky
Kentucky Children's Garden Spring Break Special!
Student Health Advisory Council Meeting
Best Practices for Tree Planting and Establishment Class 2
Selecting the Right Tree for Your Landscape Class 1
#TrendingTopics: It's Not Easy Being Green
Wed
3
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Toastmasters
Kentucky Children's Garden Spring Break Special!
Thu
4
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Softball vs. Texas A&M
UK Baseball vs. Florida
Kentucky Children's Garden Spring Break Special!
Creoles Topopholia
Religion & Politics in Anxious States
Exploring, Remixing, Analyzing: Teaching History with Digital Media
Cormac O'Grada - "The Nature of Famines"
"The Nature of Famines," Committee on Social Theory Public Lecture
Building a Rain Garden: Collaborative Effort with UK
Fri
5
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Baseball vs. Florida
UK Softball vs. Texas A&M
Bluegrass Bazaar
Sat
6
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Baseball vs. Florida
UK Softball vs. Texas A&M
Ride the Legacy
UK Men's Tennis vs. Vanderbilt
Sun
7
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Boxes & Walls: Oppression through History
Mon
8
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Explore Leadership Workshops
Boxes & Walls: Oppression through History
Job Club: Research Your Target Organization Before the Interview: What to Know and How to Find Out
#UK Kicks Butts Day
UK Softball vs. Wright State
Dine. Discover. Decide.: Connecting students to alumni in 3D!
Earth Days in the Bluegrass and the Late Night Film Series Present: Gasland Part II, A Bike-In Movie
UK Baseball vs. Morehead State
Student Sustainability Council Meeting
Tue
9
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents Fear and Loathing in Las Vegas
UK Men's Tennis vs. Ohio State
Boxes & Walls: Oppression through History
Wellness On Wheels
Get Your DIY On! Fix-It Station Demonstrations
Overview of Nursing Home Care
Spring (Bike) Fever Twitter Chat
UK Softball vs. Mississippi Valley
Best Practices for Tree Planting and Establishment Class 2
UK Men's Tennis vs. Morehead State
Wed
10
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents American Hustle
UK Toastmasters
Bike-Through Resource Fair
Undergraduate Research Group Advising Session: April General
Presentation by Ladino Rockstar, Sarah Aroeste
Mountain Biking for Beginners Clinic
LNFS presents The Mexican Suitcase
Mr. PharmD
Performance by Ladino Rockstar, Sara Aroeste
Thu
11
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Last Day to Drop a Spring 2014 Course
LNFS presents Boogie Nights
Car-Free Day
What Are They? Some Hidden Forms of the Copula in Old Irish
UK Men's Tennis vs. South Carolina
UK Baseball vs. Missouri
LNFS presents Loose Cannons
Fri
12
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Baseball vs. Missouri
UK Men's Golf Bluegrass Invitational
Arboretum Volunteer Training and Orientation
Taste of Africa
Dramatic Presentation -"Las Voces de los Apalaches"
Swing Dancing!
Sat
13
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Baseball vs. Missouri
UK Men's Golf Bluegrass Invitational
UK Men's Tennis vs. Florida
UK Men's Tennis vs. Murray State
Sun
14
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Therapeutic Chair Massage
Mon
15
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Superheroes On and Off the Page
Parenting Connection Group
Farmer's MarCat & Craft Fair
Student-Teacher-Student Exhibit
Tue
16
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents Blue Velvet
Inequality in the US: Consequences
Reframing Stress: Do You Know Your Choices?
Best Practices for Tree and Shrub Pruning Class 3
Cooking Class: For True Beginners
Pinterest Party #3
Wed
17
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents Anchorman 2
UK Toastmasters
Virtual Dementia Tour
Children at Risk Research Conference Keynote Address: Gender, Sexuality, & Risks for Violence among Young Women and LGBTQ Youth in Urban Communities
OUTspoken: Leaving the Second Closet Behind
LNFS presents Easy Rider
Thu
18
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Children at Risk Graduate Student Research Poster Presenatation
20th Annual Black Women's Conference
Children at Risk Research Conference Speaker: Why Do Home and Neighborhood Issues Become School Safety Nightmares?
The Re-enchantment of Photography as a Primanry Geographic Mapping Medium
The Re-enchantment of Photography as a Primanry Geographic Mapping Medium
UK Softball vs. Arkansas
Fri
19
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
20th Annual Black Women's Conference
UK Softball vs. Arkansas
UK Track and Field Home meet
Unleash the Beast: Paintball Wars
Sat
20
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Sun
21
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Distinguished Industry Lecture Series, H. Graham Motion and Bruce “Buck” Davidson, Jr.
Mon
22
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Explore Leadership Workshops
Job Club: Tighten Your Budget after a Job Loss
‘Project Learning Tree’ Workshop for Educators
Drug War Talk by Anthropologist Howard Campbell
Student Sustainability Council Meeting
Tue
23
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents The Lego Movie
Registration Deadline: Weight Loss Matters
Legacy Week: Ping Pong Ball Drop
Health Smart: Mindfulness
Pre-Pharmacy Club Meeting
IPM (Integrated Pest Management) and Tree Healthcare Class 4
Shuffle Series: Bluegrass
Wed
24
Exhibit: Fauna of Mexico
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
LNFS presents The Hobbit: Desolation of Smaug
UK Toastmasters
Wellness On Wheels
LNFS presents Juno
Perelman’s Dissociations: Double Fidélité, Fighting the Nazis, and the New Rhetoric Project’s Canon of Invention – Annual Hymson Lecture
Legacy Week: Candlelight Ceremony
Thu
25
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Exhibit: Fauna of Mexico
LNFS presents The Brave Little Toaster
Bonfires of Illusions: the Twin Crises of the Liberal World
Arbor Day Volunteer Orientation and Training
Alex Callinicos - "Bonfires of Illusions: The Twin Crises of the Liberal World
LNFS presents Pariah
UK Theatre presents "Joseph and the Amazing Technicolor Dreamcoat"
Color Me Spring Fashion Show
Fri
26
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Legacy Week: Leave Your Legacy
Arbor Day at The Arboretum
UK Theatre presents "Joseph and the Amazing Technicolor Dreamcoat"
Sat
27
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
UK Theatre presents "Joseph and the Amazing Technicolor Dreamcoat"
UK Wind Symphony Concert
UK Symphony & Concert Band Concert
Sun
28
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Mon
29
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Politics in Mexico Today
Tue
30
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
EPIC Ministry Weekly Gathering
Relieving Stress Through Your Senses
Tree Identification Class 5
Massage on the Go #3
The Practicing Happiness Workbook - author presentation
Wed
 
 
 
Apr 23
LNFS presents The Lego Movie 04/23/2014
Reset Page