Carl Nathe

By

Spinoff Licensed to Develop Alzheimer's Treatment

Published: Sep 22, 2011

LEXINGTON, Ky. (Sept. 21, 2011) CoPlex Therapeutics has signed an exclusive global license agreement with Hawthorn Pharmaceuticals to develop and commercialize hawAD14, a preclinical oral small molecule candidate for the treatment of Alzheimer’s and other neurodegenerative diseases.

 

According to a released statement from Hawthorn Pharmaceuticals, a commercial-stage specialty drug company, research indicates hawAD14 significantly decreases production of amyloid beta (Aβ) the major component of senile plaques and alters proteins associated with hyperphosphorylation of tau which is associated with neurofibrillary tangles present in Alzheimer's disease.

 

“In terms of the discovery’s uniqueness, it’s one of only a few programs in the world demonstrating multiple protective effects against the predominant pathogenic pathways of Alzheimer’s disease,” said Rob Lewis, chief scientific officer at Hawthorn. “We are in the process of completing necessary preclinical studies in order to file an IND (investigational new drug) with the FDA,” said Hawthorn CEO Max Draughn.

 

CoPlex co-founder and CEO John Beran said, “University of Kentucky researchers and CoPlex founding scientists Mark Lovell and Bert Lynn discovered an aberrant protein complex linked to Alzheimer’s which gave them a unique approach to begin to interrupt pathogenic mechanisms associated with the disease. They evaluated multiple compounds to see if they could minimize events on the path toward Alzheimer’s and the leading candidate was hawAD14.”

 

“The discovery of hawAD14 may be the most promising research of our professional careers,” said Mark Lovell, Jack & Linda Gill Professor of Chemistry and research faculty with the UK Sanders-Brown Center on Aging. “We are extremely excited by the potential this compound holds to slow the progression of Alzheimer’s and significantly improve the lives of individuals impacted by this terrible disease.” Lovell worked as a graduate student and postdoctoral scholar under the direction of Dr. William D. Ehmann and the late Sanders-Brown founder Dr. William R. Markesbery.

 

UK chemistry colleague and CoPlex co-founder Bert Lynn said, “While developing haw AD14, we have gained insight into possible biochemical pathways leading to neurodegeneration and are using this information to identify additional active compounds for other neurodegenerative diseases.” In addition to being a professor in the Department of Chemistry, Lynn is also a Sanders-Brown Center on Aging faculty associate and director of the UK Mass Spectrometry Facility in the ASTeCC campus incubator.

 

Lovell and Lynn have partnered with Beran on another University of Kentucky spinoff company Scout Diagnostics. The Scout technology measures levels of a novel protein biomarker — the same aberrant protein complex discovered and used to develop hawAD14 and other compounds through CoPlex.

 

According to Beran, the current Scout prototype test detects this biomarker which is tied to the progression of Alzheimer’s from its earliest manifestation as mild cognitive impairment. “This is a point early enough in the progression of the disease that next-generation therapeutics may offer the prospect of slowing further cognitive decline.”

 

“Imagine going for a check up, having blood drawn and being placed on a safe therapeutic drug that will slow the progress of Alzheimer’s so that you never experience its symptoms. This is our hope for both technologies,” said Beran, who was introduced to Lovell and Lynn by their chemistry department colleague John Anthony in 2006. Anthony and Beran are co-founders of Outrider Technologies.

 

“The CoPlex technology is moving so fast that it is hard to predict the limits on its application,” said Beran, who plans to work with Hawthorn Pharmaceuticals to develop additional drug candidates for other neurologic disorders. “We believe what Mark and Bert have uncovered will lead to better treatments for these vexing diseases.”

 

The Scout Diagnostics’ technology can be applied in different situations where it is important to know whether a patient is beginning to develop Alzheimer’s such as in clinical trials. “It is perfectly suited for a first-in-category blood test for Alzheimer’s which would be considered an in vitro diagnostic medical device,” said Beran. He is working with several companies that are interested in developing this technology.

 

Beran has also worked closely with the University of Kentucky Office for Commercialization & Economic Development, and both CoPlex Therapeutics and Scout Diagnostics are located in the ASTeCC campus incubator, managed by the UKCED office. “Between lab space, relationships with investors and networking gatherings, I’ve been able to champion my spinoff companies and their technologies forward,” said Beran. “Len Heller has a great mind for business and is a mentor to me.”

 

“We are all very pleased that CoPlex Therapeutics and Scout Diagnostics are moving closer to making significant contributions to the early detection and treatment of Alzheimer’s disease,” said Beran.

 

 

 

MEDIA CONTACTS:  Deb Weis, (859) 257-8296; Carl Nathe, (859) 257-3200

 

11-09-22_coplex2.jpg
November
 
 
 
 
 
 
1
Free Saturday Swing Dance Lessons
College of Pharmacy Open House
Iron Pour
UK Women's Choir 20th Anniversary Concert
Adventure Hiking & Rappelling @ Red River Gorge
Pickin' Time Mountain Music and Harvest Day
Purposeful Retirement: Planning Your Next Stage of Life
Diwali Dhoom 2014
Sat
2
UK Percussion Ensemble
Day Hike
Curator Tour: Take My Word For It
Sun
3
Industry Career Week: Resumes and Cover Letters
Kentucky Volleyball vs. Morehead State
Mon
4
Industry Career Week: How to Impress Your Boss in 90 Days
Rock Star Professionalism Series
UK Lab Band
Tue
5
Industry Career Week: Networking and Job Search
Social Enterprise and Innovation / Certified Nonprofit Professional Program Informational Meeting
Circle of Love Name Distribution
Appalachian Forum with Dr. Fran Ansley
Dana Harper Gallery Reception
Wed
6
Career Assessment Workshop
LNFS Presents: Zona Sur
LNFS Presents: The Grand Budapest Hotel
UK Jazz Ensemble
Circle of Love Name Distribution
Abstract Workshop
Lauren Potter
Thu
7
LNFS Presents: V for Vendetta
Last Day to Withdraw or Reduce Course Load
Circle of Love Name Distribution
R.C. May Photography Lecture Series: Marvin Heiferman
Men's Soccer vs. Charlotte
Kentucky Volleyball vs. Georgia
Free Friday Evening Swing Dance
Fri
8
Kentucky Football vs. Georgia
Free Saturday Swing Dance Lessons
The Power of Poetry
The Lexington Lowdown and Free Lindy Hop Workshop
Swing Dance Featuring Live music by"The Metrognomes Orchestra"
Sat
9
UK Combos Concert
Kentucky Volleyball vs. Missouri
Sun
10
Circle of Love Name Distribution
Mon
11
UK Sax Ensembles
Job Club - Interviewing Strategies
Undergraduate Research Information Session
Jose Abisambra Presentation on Current Alzheimer's Research
Women of the World: Judy Smith
Tue
12
Internship Info Session
LNFS Presents: Reservoir Dogs
Refugee Life in America
#UKEDTALKS: International Opportunities for Education Majors
Leadership Assessment
Wed
13
Career Assessment Workshop
LNFS Presents: Iron Man 3
Chili and Pie Cook-Off Supper
#TrendingTopics: Vegetarians vs. Meat-Eaters
Campus Polar Plunge to benefit Special Olympics KY
LNFS Presents: La Demora
Thu
14
LNFS Presents: Pretty in Pink
LNFS Presents: Mean Girls
Fri
15
Free Saturday Swing Dance Lessons
Sat
16
Kentucky Volleyball vs. Florida
Greek Cinematography: Critical Approach and Discussion
"Storied Streets" Documentary Showing about Experiences of Homelessness
Sun
17
The Vexillology (the study of maps) Contest
UK Rep Bands Concert
College of Agriculture, Food & Environment 2014 Celebration of Land-Grant Research
Amanda Rogers, "Black Flags, ISIS 'Swag' & Jihadi Rap: Marketing Militancy after the Arab Spring"
Stories of Homelessness: Panel Discussion
Mon
18
The Vexillology (the study of maps) Contest
A Positive Approach to Caregiving Conference
Education Abroad Open House
CatWatch Party
Appalachian Forum and Film Screening of "Up the Ridge"
Tue
19
The Vexillology (the study of maps) Contest
LNFS Presents: The Princess and the Frog
Pinterest Party
International Games Day
Global Design with Phil Duncan
Caregiver Support Group
OXFAM Social Issues Banquet
Wed
20
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: I Travel Because I Have To, I Come Back Because I Love You
LNFS Presents: The Big Lebowski
International Education Week Keynote Speaker: Christie Vilsack, Senior Advisor for International Education at USAID
Tobacco-free Tailgate 5 Year Anniversary
Bollywood Night
Thu
21
The Vexillology (the study of maps) Contest
Much Ado About Nothing
LNFS Presents: Water For Elephants
4th Annual Markesbery Symposium on Aging & Dementia
Freedom from Fear: On Black Childhood and Other Dangers
Bouldering @ Stone Fort
MEAT.
Fri
22
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
Free Saturday Swing Dance Lessons
Sat
23
The Vexillology (the study of maps) Contest
Much Ado About Nothing
Bouldering @ Stone Fort
UK Symphony Band and UK Concert Band
Sun
24
The Vexillology (the study of maps) Contest
Free Thanksgiving Shuttle to Blue Grass Airport
Mon
25
Free Thanksgiving Shuttle to Blue Grass Airport
Job Club - What is your money habitude?
Multicultural Student Thanksgiving Dinner
Tue
26
Thanksgiving - Academic Holidays
Free Thanksgiving Shuttle to Blue Grass Airport
Wed
27
Thanksgiving - Academic Holidays
Thu
28
Thanksgiving - Academic Holidays
Fri
29
Thanksgiving - Academic Holidays
Free Saturday Swing Dance Lessons
Kentucky Volleyball vs. Arkansas
Sat
30
 
Sun
 
 
 
 
 
 

Wed, 11/26/2014 - Sat, 11/29/2014

Wed, 11/26/2014

Repeats every week until Sat Nov 29 2014 except Sat Sep 20 2014, Sat Oct 18 2014.
Sat, 11/29/2014

Sat, 11/29/2014

Mon, 12/01/2014

Reset Page