Whitney Harder

By

College: Arts and Sciences

UK Chemistry Researchers Develop Metal Complexes To Study Cancer

Published: Jan 11, 2016

LEXINGTON, Ky. (Jan. 11, 2015) — University of Kentucky Department of Chemistry researchers Edith Glazer, Sean Parkin and students Erin Wachter and Diego Moyá recently published a study showing that specialized compounds containing the metal ruthenium may be able to visualize or damage specific DNA structures relevant for cancer.

 

Published in "Chemistry - A European Journal," the work was named a "Hot Paper" for its importance in a rapidly evolving field of high interest, and was highlighted with the back cover.

 

The ends of chromosomes and some genes associated with cancer have regions where DNA can form unusual structures known as G-quadruplexes, of which there are several subtypes. For cancer cells to continue growing and dividing, they need to untangle these G-quadruplex structures. Researchers have long thought it would be possible to halt tumor growth if there was a way to lock these G-quadruplex structures in place.

 

Graduate students Erin Wachter and Diego Moyá synthesized ruthenium-containing compounds they thought might bind and stabilize G-quadruplex structures. They designed these potential drugs to act as “light switches” so they would only give a response when bound to G-quadruplex structures. Using a rapid screening approach, they found two compounds that were exquisitely specific for distinct G-quadruplex structure subtypes. Out of 32 biomolecules they tested, two different G-quadruplexes  showed the greatest response to the ruthenium compounds.

 

In collaboration with Parkin, they used X-ray crystallography — a technique that allows researchers to determine the chemical structure of molecules  to investigate the structural differences in the two complexes that could relate to the differences in selectivity.

 

"It's pretty rare to have molecules that recognize or damage specific DNA structures," Glazer said. "Most molecules prefer [the more common] double helix DNA and the selectivity within different subclasses of molecules is really unusual."

 

In the future, derivatives of these compounds may be used to visualize or damage cancer cells.

 

This research was funded by the American Cancer Society and the National Institutes of Health.

 

 

 

MEDIA CONTACT: Whitney Harder, 859-323-2396, whitney.harder@uky.edu

image_m_mcontent.png
July
 
 
 
 
 
1
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Music Education Summer Training
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Eugene Meatyard & Duane Michals: Camera Drama
Fri
2
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Independence Day - Academic Holiday
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
5
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
6
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
7
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
8
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
9
UK Writing Center Open for Summer Session 2 (June 9-August 4)
FAMILY DAY WORKSHOP
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
10
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
11
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
12
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
13
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Birdhouse Display and Auction
Wed
14
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
15
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Curator Tour
Fri
16
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
17
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
18
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
19
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
UK Women's Forum Board Meeting
Tue
20
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
21
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
22
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Fri
23
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
24
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
25
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Mon
26
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Tue
27
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Wed
28
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Thu
29
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Reading Fairy Tales
Fri
30
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sat
31
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Birdhouse Display and Auction
Natalie Frank: The Brothers Grimm
Lawrence Tarpey: Figures & Grounds
Eugene Meatyard & Duane Michals: Camera Drama
Sun
 
 
 
 
 
 

Repeats every day until Sun Jul 31 2016 .
Sat, 07/02/2016

Repeats every day until Sun Jul 31 2016 .
Sun, 07/03/2016

Reset Page