Keith Hautala

By

College: Pharmacy

UK Pharmacy Professor Develops New Tool to Prevent Heroin Deaths

Published: Aug 7, 2014

 

Video by UK Research Media

 

 

LEXINGTON, Ky. (Aug. 7, 2014) — A new, lifesaving product aimed at reducing the death toll from heroin abuse — developed by a professor at the University of Kentucky College of Pharmacy — is in its final round of clinical trials and has received Fast Track designation by the Food and Drug Administration.

 

The product, a nasal spray application of the anti-opioid drug naloxone, was developed by Daniel Wermeling, UK professor of pharmacy practice and science, through his startup company AntiOp Inc.

 

Naloxone is the standard treatment for suspected opioid overdose, already in use by emergency rooms and emergency medical technicians across the country. Opioids are the class of pain-killing drugs that are related to morphine, including prescription drugs such as hydrocodone and oxycodone, as well as illegal drugs such as heroin.

 

Currently, naloxone is administered by injection. The nasal spray eliminates the need for needles, with a ready-to-use, single-use delivery device inserted into the nose of an overdose victim. The product delivers a consistent dose, absorbed across the nasal membranes even if the patient is not breathing.

 

"The goal is to make the medication available to patients at high risk of opioid overdose, and to caregivers, including family members, who may lack specialized medical training," Wermeling said. "The treatment could be given in anticipation of EMS arrival, advancing the continuum of care and ultimately saving lives."

 

Nationwide, deaths from opioid overdose are on the rise, according to data from the Centers for Disease Control and Prevention. Kentucky, long troubled by widespread abuse of prescription opioids, has seen a dramatic rise in deaths from heroin overdose in recent years. In autopsies from 2013, the state medical examiner attributed 230 deaths to heroin overdose, an increase of more than 60 percent from the previous year.

 

UK President Eli Capilouto congratulated Wermeling on his success with AntiOp, saying that it reflects the core values of the university.

 

"Too many Kentucky families have experienced the tragedy of seeing a loved one's life cut short by a drug overdose," Capilouto said. "The epidemic of opioid abuse in our state presents an enormous and urgent challenge, not only for health care providers and law enforcement, but also for us here at the University of Kentucky. Dr. Wermeling's project is putting a powerful new tool into the hands of those on the front line of the fight against heroin, both here in Kentucky and beyond. This type of innovation embodies the three main components of the university's mission — education, research and, above all, service."

 

UK College of Pharmacy Dean Timothy S. Tracy said Wermeling's work also provides an illustration of "bench-to-bedside" research in action.

"Dr. Wermeling’s project is a great example of how UK College of Pharmacy faculty are working each and every day to create healthier Kentucky communities," Tracy said. "Dr. Wermeling and his collaborative team of research colleagues saw a problem facing families in Kentucky and across the nation and developed an innovative solution. That type of translational approach is important to our college, this university, and, of course, the future of our Commonwealth."

 

Wermeling's research was supported by a three-year, $3 million grant from the National Institutes of Health through the National Institute on Drug Abuse with additional funding from the Kentucky Science and Technology Corporation. In May, AntiOp partnered with Reckitt Benckiser Pharmaceuticals to accelerate production and worldwide marketing of intranasal naloxone.

 

The Fast Track program of the FDA is designed to expedite the development and review of new drugs that are intended to treat serious or life-threatening conditions and that demonstrate the potential to address unmet medical needs. Fast Track-designated drugs ordinarily qualify for priority review, thereby expediting the FDA review process.

 

"As an educator, pharmacist, researcher and entrepreneur, being able to work on this naloxone project has been a dream come true," Wermeling said. "I often tell my students and colleagues that this project has allowed me to use all of the skills I have learned over the years. It has been the ultimate problem-solving project, requiring me to utilize my pharmacological skills, my drug delivery knowledge, my business and marketing skills — all at the same time.

 

"At the end of the day, however, this project has always been about people. It has always been about utilizing the knowledge and skills that we have to improve patient care."

 

MEDIA CONTACT: Keith Hautala, 859-323-2396; keith.hautala@uky.edu

wermeling.jpg
February
 
1
Graduate Student Congress Meeting (February)
Mon
2
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Tue
3
K Crew Recruitment
Last Day to Drop a Course Without Appearing on Transcript
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Wed
4
K Crew Recruitment
Bill Adams: Blue Madness
Undergraduate Research Information Session
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
5
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Explore Blue
Off-Campus Student Services' Wildcat Apartment Hop #1
Panel Discussion: Historic Homes
Fri
6
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
7
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
8
K Crew Recruitment
Sex and Chocolate
Law School Prep Workshop
Mon
9
K Crew Recruitment
Healthy Relationships Workshop
How to Package Communication and Technical Skills on your Resume
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
2016 Distinguished Industry Lecture Series
Tue
10
K Crew Recruitment
Last Day to Receive 50% Refund
Pinterest Party #1
Off-Campus Student Association Information Session
Get Yourself Tested!
Showcase your Talents: Building a Strong Portfolio
An Evening with Tatyana Ali and Amir Windom: Progression Towards Success
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
How to Survive a Plague
Wed
11
K Crew Recruitment
Coffee & Canvases
Off-Campus Student Association Information Session
Study Abroad in Berlin!
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
12
K Crew Recruitment
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Fri
13
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Workshop: The Artist Statement
Sat
14
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
15
K Crew Recruitment
See ICT
Patterson School Guest Speaker Series
Mon
16
K Crew Recruitment
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
See ICT
UK Women's Forum February Board Meeting
Tue
17
K Crew Recruitment
Food For Thought
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Wed
18
Undergraduate Research Information Session
Soup & Substance: Real Talk, Real Issues, & Real People Series
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
19
PharmD Interviews
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Off-Campus Student Services' Wildcat Apartment Hop #2
SAB Underground Formal
Fri
20
PharmD Interviews
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sat
21
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Sun
22
Undergraduate Research Information Session
Mon
23
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Tue
24
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK Elder Care Lunch & Learn - Don't Blame It On Aging
Ravi Zacharias at Memorial Coliseum
Wed
25
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Thu
26
Explore Blue
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Dimensions of Political Ecology Conference
Eday Talk by Georgetown Toyota President Wil James
Do What You Are: Connecting Personalities w/ Profession
Off- Campus Student Services' Wildcat Apartment Hop #3
Concert in the Museum: Central Music Academy
Fri
27
Dimensions of Political Ecology Conference
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
UK E-Day
Sat
28
Bill Adams: Blue Madness
Bill Adams: Blue Madness
Bill Adams: Blue Madness
DanceBlue Rave Hour
Bill Adams: Blue Madness
Open House: Selections from the John and Sue Wieland Collection
Open House: Selections from the John and Sue Wieland Collection
Sun
29
Monday through Friday - Midterm Grading window is open. The mid-term grading window will close at midnight on March 11.
Monday through Wednesday - Students are prohibited from changing academic major
Bodies Of Evidence: Provocations: A Transnational Feminist History Project
Mon
 
 
 
 
 
Feb 07
Bill Adams: Blue Madness 02/07/2016

Mon, 02/08/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Sun Apr 03 2016 .
Tue, 02/09/2016

Repeats every day on January, February, March, April every Sunday and every Tuesday and every Wednesday and every Thursday and every Friday and every Saturday until Mon Apr 04 2016 .
Tue, 02/09/2016

Reset Page