Allison Perry

By

College: Pharmacy

UK Study Reveals New Method to Develop More Efficient Drugs

Published: Jul 6, 2015

LEXINGTON, Ky. (July 7, 2015) – A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.

 

Published in Nanomedicine, the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer, thus reducing or possibly even eliminating their resistance to targeted drugs.

 

The study was led by Peixuan Guo, director of UK's Nanobiotechnology Center and one of the top nanobiotechnology experts in the world. Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy.

 

"Efficacy is the key in drug development,” Guo said. "Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains; one broken bulb turns off the entire lighting system."

 

By targeting RNA or protein subunits that have multiple sites for inactivation, but that are inextricably linked, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable (and thus, multiple drugs are not needed, as well).  Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism, the organism will be disabled or die and thus, no longer able to cause disease.

 

“One of the vexing problems in the development of drugs is drug resistance,” said Tim Tracy, former Dean of the UK College of Pharmacy and current UK provost. “Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism, such that resistance is minimized or eliminated.”  

 

Guo focuses much of his work on the use of ribonucleic acid (RNA) nanoparticles and a viral nano-motor to fight cancer, viral infections and genetic diseases. He is well-known for his pioneering work of constructing RNA nanoparticles as drug carriers. Guo's research team also includes Dan Shu, Farzin Haque, Mario Vieweger, Fengmei Pi, Hui Zhang, Yi Shu, Chi Wang, Peng Zhang, Ashwani Sharma, Taek Lee and more than 10 graduate students.

 

MEDIA CONTACT: Allison Perry, (859) 323-2399 or allison.perry@uky.edu 

screen_shot_2015-07-07_at_3.10.15_pm.png
August
 
1
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Mon
2
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Tue
3
UK Writing Center Open for Summer Session 2 (June 9-August 4)
Wed
4
UK Writing Center Open for Summer Session 2 (June 9-August 4)
End of the Summer II 2016 Eight-Week Session
Thu
5
 
Fri
6
 
Sat
7
 
Sun
8
 
Mon
9
 
Tue
10
 
Wed
11
 
Thu
12
 
Fri
13
Parent and Families Open House
Sat
14
 
Sun
15
 
Mon
16
UK Women's Forum Board Meeting
Tue
17
 
Wed
18
 
Thu
19
K Week Kick-off
Off-campus Freshmen Check-in
Parent and Families Reception
Fri
20
New Student Induction Ceremony
Big Blue U
Getting Around Campus and Beyond
Campus Ruckus
Sat
21
UK Lex-Mart
K Team Lunch
Late-night Target Run
Sun
22
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Dinner with your K Team
Mon
23
We Are UK
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
TEAL Classrooms Open House
Campus Tours for K Teams
Tue
24
First Day of School Photos
First day of classes of Fall 2016
Wed
25
Pedalpalooza
First Day of School Photos
Thu
26
OCSS Wildcat Block Watch
Fri
27
Louis Zoellar Bickett: Saving Myself
Red River Gorge Adventure Trip for Out-of-State Students
Music Workshop for Teachers and Students: Michael Chandler
Flight 5191 Tenth Anniversary Memorial Service
Sat
28
Louis Zoellar Bickett: Saving Myself
Sun
29
Louis Zoellar Bickett: Saving Myself
Mon
30
Louis Zoellar Bickett: Saving Myself
Last Day to Add a Class for Fall 2016
Last Day to Withdraw to Receive 80% Refund
Tue
31
Louis Zoellar Bickett: Saving Myself
Wed
 
 
 
Reset Page